Type: Article
A new and facile access to the 2-(indol-3-yl)-3-nitriloquinolines based on Friedländer annulations
Journal: Tetrahedron (14645416)Year: 29 July 2012Volume: 68Issue: Pages: 6059 - 6064
Shiri M. Zolfigol M.A. Pirveysian M. Ayazi-Nasrabadi R. Kruger H.G. Naicker T.Mohammadpoor Baltork I.a
DOI:10.1016/j.tet.2012.05.006Language: English
Abstract
Preparation of 2-(indol-3-yl)-3-nitriloquinolines via Friedländer quinoline synthesis using 3-cyanoacetylindoles possessing an α-methylene group and ortho-amino arylketones have been described. This reaction took place in PEG-400 as a green solvent and it is catalyzed with polyphosphoric acid (PPA) to give novel types of quinolines containing both indoles and cyano functions in one step under thermal and microwave conditions. © 2012 Elsevier Ltd. All rights reserved.