A novel one-pot synthesis of fully substituted thiophen-2(3H)-ones using N,N-disubstituted thioamides

Abstract

A new one-step synthesis of highly substituted thiophen-2(3H)-one derivatives was developed. 2-Aryl-1-(morpholin-4-yl)ethanethiones were reacted with 2-chloro-2-phenylacetyl chloride in DMF in the presence of a base to give the title compounds in moderate-to-good yields. Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich, Switzerland.