Type: Article

A novel one-pot three-component approach to 4-amino-functionalized spiropyrimidine-2-thiones

Journal: Journal Of The Iranian Chemical Society (1735207X)Year: 1 June 2019Volume: 16Issue: Pages: 1139 - 1146

Zali Boeini H.^a Karimi F.Khayat Z.Amiri Rudbari H.^a Abbasi A.

a :University of Isfahan - IRAN(IR) - Isfahan

DOI:10.1007/s13738-018-01589-9Language: English

Abstract

A series of 4-amino-functionalized spiropyrimidine-2-thione derivatives were simply produced by the one-pot three-component reaction of alicyclic carbonyl compounds, nitriles containing an acidic methylene, and thiourea in the presence of NaOMe in MeOH. © 2019, Iranian Chemical Society.

Author Keywords

CyclizationMulticomponent reactionsSpiro compoundsSynthetic methods