Type: Article

Anderson-type manganese polyoxomolybdate hybrid nanocomposite for boosting drug delivery against breast cancer

Journal: Journal of Drug Delivery Science and Technology (17732247)Year: September 2023Volume: 87Issue:

Azimian V.^aTaymouri, Somayeh Mirian M.Ramezani-Aliakbari M. Rostami M.

a :University of Isfahan - IRAN(IR) - Isfahan

DOI:10.1016/j.jddst.2023.104778Language: English

Abstract

Novel biocompatible nanocomposites (NCs) of Anderson-type manganese polyoxomolybdate (MnMo6) in chitosan imidazolium platform (MnMo6@CSIm NCs) were introduced for modulating cytotoxicity profile. The anticancer activity of optimized NCs was evaluated against breast cancer cell lines (MCF-7 & MDA-MB-231) and HUVEC normal cells using the MTT assay. Cellular uptake, apoptosis ratio, and cell migration inhibition were also evaluated on the MDA-MB-231 cell line. The optimized pH-responsive NCs had better anticancer activity than free MnMo6 without cytotoxicity against normal HUVEC cells. The cellular uptake was about 100%, and the apoptosis value was higher (81%) than free MnMo6. Interestingly, the MnMo6@CSIm NCs inhibited the cell migration 1.5 times better than the free MnMo6. These results are fascinating to follow more pre-clinical studies. © 2023 Elsevier B.V.