Association of CD24V/V genotype with susceptibility and progression of multiple sclerosis in Iranian population

Abstract

A single nucleotide polymorphism (SNP) in CD24 has been associated with multiple sclerosis (MS) in a population based study. This SNP results in the replacement of alanine (CD24A) by valine (CD24V) at amino acid 57 in the resulting polypeptide chain. In the current study, the genotyping of this SNP and its contribution to MS in 217 patients and 200 healthy individuals of an Iranian population was investigated. The correlation of the SNP alleles with the progression of the disease was determined using the expanded disability status scale (EDSS) and progression index (PI). The data revealed that individuals with the CD24V/V genotype showed a 2-fold increase in the relative risk of MS compared to patients with the CD24A/V (0.27) and CD24A/A (0.25) genotypes (P = 0.0193, Odds Ratio 2.4882, 95% CI: 1.416-4.3722). Moreover, the progression of the disease in patients with CD24V/V was much faster than other patients that were examined by ANOVA and the least significant difference (LSD) test. However, in the CD24V/V patients LSD analysis was statistically significant (p<0.05 and p<0.01). These results support the hypothesis that CD24 may function as a genetic modifier for susceptibility and progression of MS through the CD24V/V genotype.