Bioinformatics comparison of G protein of isfahan virus with the same proteins of two other closely related viruses of the genus Vesiculovirus

Abstract

Since there are not much experimental data available about different structural properties of Isfahan virus (ISFV), in the present investigation, computational study of G protein of ISFV was performed and the results were compared with G proteins of Chandipura virus (CHPV) and Piry virus (PV).Calculation of amino acid compositions of G proteins of viruses was done by PseAAC server.Predictions of localization, sequence of signal peptides, C, N and O glycosylation sites, transmembrane helices, cysteine bond positions and B cell epitopes of G proteins were performed by Virus- PLoc, Signal-CF, EnsembleGly, MemBrain, DiANNA and BCPREDS servers respectively.Similarities and differences between these glycoproteins were predicted and discussed. © 2009 Bentham Science Publishers Ltd.