Type: Article

CsF-Catalyzed Transannulation Reaction of Oxazolones: Diastereoselective Synthesis of Diversified trans- N-(6-Oxo-1,4,5,6-tetrahydropyrimidin-5-yl)benzamides with Arylidene Azlactones and Amidines

Journal: ACS Combinatorial Science (21568952)Year: 11 June 2018Volume: 20Issue: Pages: 358 - 365

Parhizkar G. Khosropour A.R.Mohammadpoor Baltork I.^a Parhizkar E.Amiri Rudbari H.^a

a :University of Isfahan - IRAN(IR) - Isfahan

DOI:10.1021/acscombsci.8b00027Language: English

Abstract

A versatile and straightforward synthetic strategy for the construction of new tetrasubstituted 1,3-diazinones is described. The procedure is based on CsF-catalyzed, microwave-assisted, ring transformation reaction of arylidene azlactones with amidines. Moreover, this technique provides diversified trans-N-(6-oxo-1,4,5,6-tetrahydropyrimidin-5-yl)benzamides with a good antimicrobial activity. © 2018 American Chemical Society.

Author Keywords

amidineazlactoneCsFdiastereoselectivetransannulation reaction

Other Keywords

Anti-Bacterial AgentsBacillus subtilisBenzamidesCatalysisCesiumEscherichia coliFluoridesMolecular StructureOxazolonePyrimidinesStaphylococcus aureusStereoisomerismantiinfective agentbenzamide derivativecesium fluoridefluoridepyrimidine derivativeanalogs and derivativeschemical structurechemistrydrug effectsynthesis