Effect of acute and prolonged periods of aerobic training and detraining on novel inflammatory marker: The predictive of cardiovascular disease in Wistar rats

Abstract

Aim. The purpose of this study was to determine the effect of acute and prolonged periods of aerobic training and detraining on novel inflammatory marker the predictive of cardiovascular disease in Wistar rats. Methods. Forty-two male rats divided randomly into two groups: aerobic training group (experimental) (N.=24) and control group (N.=18; without any training program). Experimental group trained for 12 weeks, three times a week, with the definite speed and duration. To study the effects of detraining, six trained rats were taken off of training regimen after 24 sessions of training. The blood samples were gathered in different phases of training. A cellular adhesion molecule (sICAM-1) was measured with ELISA kits following the manufacturer's protocol. Data were analyzed by two way ANOVA and different and independent t-test. Results. The results showed that sICAM-1 levels were decreased insignificantly (P=0.179) in the first 8 weeks, but a significant decrease was observed in sICAM-1 concentration (P=0.001) as the training continued to 36 sessions. Also, it was revealed that by detraining, the gained adaptation faded out and the body was exposed to the danger of atherogenesis damages (P=0.07). Conclusion. In conclusion, the findings of this study indicate that the measurement of sICAM-1, is beneficial for the diagnosis of different environmental factors on vascular disorders and that the regular aerobic training would be a helpful mean in prophylaxis and reduction of atherosclerosis by lowering the concentration of sICAM-1.