Type: Article

Folic acid bonded (Bu4N)5H4[P2W15V3O62] as a smart hybrid compound for cancer cells targeting

Journal: Polyhedron (02775387)Year: 1 December 2021Volume: 210Issue:

Alizadeh M.Yadollahi B.^aAbbasi Kajani A.^a

a :University of Isfahan - IRAN(IR) - Isfahan

DOI:10.1016/j.poly.2021.115510Language: English

Abstract

A new hybrid compound was synthesized via the covalent grafting of vanadium-substituted Wells-Dawson type polyoxometalate (Bu4N)5H4[P2W15V3O62] to folic acid. The cytotoxic effect of the resulted bioactive hybrid compound was investigated on cervical (HeLa) and human breast (MCF-7) cancer cells. Interestingly this smart hybrid compound could knockdown cancer cells (IC50 about 19 and 75 µgmL−1 for HeLa and MCF-7 respectively), while the normal cells, as a folate receptor (FR) negative cell, remained nearly untreated (IC50 about 317 µgmL−1). Higher cytotoxicity of this hybrid polyoxometalate on HeLa than MCF-7 cells could be attributed to the higher expression of folic acid on HeLa. The IC50 for (Bu4N)5H4[P2W15V3O62] on healthy cells (about 84 µgmL−1) showed four times improvement in the polyoxometalate biocompatibility by incorporation of folic acid. In comparison to methotrexate (as a positive control), this smart polyoxometalate-folic acid hybrid compound has a high potential for developing a significant and selective therapeutic effect against FR-positive cancer cells. © 2021 Elsevier Ltd

Author Keywords

Bioactive hybrid compoundFolate receptionFunctionalized polyoxometalateOrganic–inorganic compoundSmart targeting

Other Keywords

BiocompatibilityCellsCytologyDiseasesInorganic compoundsLanthanum compoundsOrganic acidsOxidesBioactive hybrid compoundBioactivesFolate receptionFolatesFunctionalizedFunctionalized polyoxometalateHybrid compoundsOrganic-inorganic compoundPolyoxometalatesSmart targetingCancer cells