Highly efficient and versatile one-pot synthesis of substituted thienylidene compounds

Abstract

A novel, efficient, and very mild one-pot synthesis of methyl 2-[(Z)-4-aryl-5-morpholino-3-oxo-2,3-dihydrothiophen-2-ylidene]acetate derivatives under kinetic control has been developed. The title compounds were prepared by the reaction of thioacetomorpholides with dimethyl acetylenedicarboxylate (DMAD) in the presence of K2CO3 in a non-polar solvent with excellent yields. © 2005 Taylor & Francis.