MMP-9 promoter polymorphism associated with tumor progression of breast cancer in Iranian population
Abstract
Matrix metalloproteinase-9 (MMP-9) gene plays an important role in several cancers development and progression including breast cancer. A single nucleotide substitution (C→T) in the MMP-9 promoter results in high expression of this gene and so affects susceptibility of tumor invasion and metastasis in some cancers. The aim of this study was to investigate the influence of C/T polymorphism on the occurrence and progression of breast cancer. This case-control study included 180 breast cancer patients and 100 healthy age-matched controls. Polymorphism in the promoter region (C-1562T) was genotyped by polymerase chain reaction-restriction fragment length polymorphism assay and sequencing. After data analyzing, a correlation was observed between the T allele (OR=3.27; P=0.004) and breast cancer occurrence. And also a high significant association was found between the occurrence of the T allele and progression and invasion of breast cancer (OR=5/85; P=0.000). The results suggest that the T allele of the C/T MMP-9 promoter polymorphism can be associated with the tumor development, progression and invasive phenotype of breast cancer, therefore it could be considered as a progression marker in this disease. © IJIB, All rights reserved.