One-step synthesis of imidazo[1,2-a] pyridines in water

Abstract

A novel straightforward method for the synthesis of 2,3-disubstituted imidazo[1,2-a]pyridine derivatives in water as a truly safe and cheap reaction medium was developed. Hence, N-alkyl pyridinium and S-alkyl thiouronium salts were reacted in the presence of NaHCO3 as a mild base in water to produce imidazo[1,2-a]pyridines in moderate to excellent yields. © 2016 The Royal Society of Chemistry.