Type: Article
One-step three-component and solvent-free synthesis of thiazoles from tertiary thioamides
Journal: Journal Of The Iranian Chemical Society (1735207X)Year: 1 September 2016Volume: 13Issue: Pages: 1571 - 1577
Zali Boeini H.a Mansouri S.G.
DOI:10.1007/s13738-016-0873-3Language: English
Abstract
Abstract: A novel one-pot three-component reaction has been developed for construction of thiazole derivatives under solvent-free conditions. Hence, tertiary thioamides, α-haloketones, and NH4OAc were grinded together and allowed to react thermally at 110 °C and/or under microwave irradiation to produce the corresponding thiazole derivatives in very good yields. Graphical Abstract: [Figure not available: see fulltext.] © 2016, Iranian Chemical Society.