Outcomes of testosterone enanthate on kidney of male Wistar rats subjected to resistance training[Effets de l’énanthate de testostérone sur les reins de rats mâles Wistar soumis à un entraînement en résistance]

Abstract

Background Anabolic androgenic steroids (AAS) are the most common doping agents in the sports and AAS abusers may show different renal side effects. The purpose of this study was to determine the effects of 8 weeks testosterone enanthate (TE) injection and resistance training (RT) on kidney in male Wistar rats. Materials and methods Twenty-eight male adult Wistar rats were randomly divided into 4 groups; C: control, RT: resistance training, TE: testosterone enanthate, TE + RT. Resistance training protocol consisted of climbing (5 reps/3 sets) a ladder for 8 weeks. TE and placebo (20 mg/kg BW, IM) were injected twice a week. At the end, rats were euthanized and serum biochemical analysis and pathological examinations of kidney tissue were conducted. Results serum creatinine concentration in RT group was significantly (P < 0.05) higher than that in TE and TE + RT groups and mild hyperemia and congestion were observed in all treatment groups. Conclusion Although, we showed that 8 weeks consumption of TE (20 mg/kg) accompanied with RT does not negatively affect renal function, but further studies are necessary to obtain more detailed information. © 2017 Elsevier Masson SAS