P-Toluidine-acetic acid as a catalyst for a one-pot efficient synthesis of quinoxaline and pyridopyrazin derivatives contain polyhydroxy chain with use of monosaccharides

Abstract

o-Phenylenediamine derivatives and 2,3-diaminopyridine react with d-monosaccharides in ethanol-water in the presence of a catalytic amount of acetic acid along with p-toluidine under reflux condition to afford the corresponding quinoxalines or pyridopyrazin in high yields. These structures were confirmed by FT-IR, 1H-NMR, 13C-NMR, elemental analysis and single-crystal X-ray analysis. Graphical Abstract: [Figure not available: see fulltext.] © 2014 Iranian Chemical Society.