Type: Article

A simple and efficient large-scale synthesis of 3-hydroxyphthalans via oxa-Pictet-Spengler reaction catalyzed by nanosilica sulfuric acid

Journal: Tetrahedron Letters (00404039)Year: 2011/03/16Volume: Issue: 11

Khorsandi Z. Khosropour A.R.Mirkhani V.^aMohammadpoor Baltork I.^aMoghadam M.^a

a :University of Isfahan - IRAN(IR) - Isfahan

DOI:10.1016/j.tetlet.2011.01.037Language: English

Abstract

Nanosilica sulfuric acid is found to be a new, powerful and reusable heterogeneous catalyst for the rapid synthesis of 3-hydroxyphthalans via condensation of aromatic aldehydes and 3-hydroxybenzyl alcohols under conventional heating and microwave irradiation. Scale-up preparation of these heterocycles is also carried out. © 2011 Published by Elsevier Ltd.