All-trans retinoic acid in Alzheimer’s disease

Abstract

Alzheimer’s disease is a complicated neurodegenerative disorder. It is characterized by the pathological accumulation of amyloid-β peptides and neurofibrillary tangles within the brain, which leads to severe cognitive damage. Studies indicate that retinoid signaling in the brain might have crucial impacts on the pathogenesis of Alzheimer’s disease. All-trans retinoic acid is an active metabolite of vitamin A in the brain and has been argued to have beneficial effects in Alzheimer’s disease. In this chapter, the latest findings on the potential prophylactic and therapeutic effects of retinoid signaling on Alzheimer’s disease will be described. Meanwhile, developing insights into possible mechanisms by which retinoic signaling in the brain modulate aspects of Alzheimer’s disease will be discussed. © 2020 Elsevier Inc. All rights reserved.