Convenient, efficient synthesis of amide-thioethers in ionic liquids

Abstract

An improved method for the synthesis of carboxamide ligands containing thioether donor sites is described. This replaces the pyridine as the reaction medium used in the classical method by tetrabutylammonium bromide. The desired products, 1,4-bis[o-(R-2-carboxamidophenyl)]-1,4-dithiobutane, R=quinoline (1), furan (2), thiophene (3), pyridine (4), and pyrazine (5), were obtained in good yields and shorter reaction times. © Taylor & Francis Group, LLC.