Current biocompatible materials in oral regeneration: A comprehensive overview of composite materials

Abstract

Reconstructive orthodontics is increasingly benefiting from regenerative medicine and tissue engineering strategies. The scaffolds used both in reconstruction or in the regenerationof dental/oral defects are mainly are from two sources of materials: biologic or organic.The biologic materials have been used for regeneration and functional reconstruction ofdefected or lost tissues. The 3D scaffold from organic materials, including; collagen andhyaluronic acid derivatives with macromolecular properties similar to natural ECM. Boneand dentine regeneration is a growing field of research in dentistry and envisions clinicalpromises by improving the outcomes for the treatment of craniofacial repair and replacement. This has been recently accelerated with innovative materials and bioactive moleculesand growth factors using in vitro or in vivo bioreactors. Both scaffolds made from biologic andorganic materials have been combined with adult stem cells with mesenchymal phenotypein a biomimicry approach to creating the more natural-like bone substitutes. This researchcritically reviewed the literature in the past ten years from databases (PubMed and NCBI). © 2020 The Authors.