Efficient deprotection of tetrahydropyranyl ethers by bismuth(III) salts

Abstract

Treatment of tetrahydropyranyl(THP) ethers with bismuth(III) salts including BiC13, Bi(TFA)3 and Bi(OTf)3 in methanol provides a simple and efficient process for deprotection of these ethers and the parent alcohols were obtained in excellent yields.