Oxidative kinetic resolution of alkyl aryl sulfoxides

Abstract

Kinetic resolution is observed in the oxidation of racemic alkyl aryl sulfoxides using a combination of VO(acac)2 and ligand 1 in chloroform at 0 °C, conditions previously described for asymmetric oxidation of prochiral sulfides. Kinetic resolution is also observed in toluene as the solvent, although higher temperatures are required. © Georg Thieme Verlag Stuttgart.