Selective and efficient oxidative deprotection of trimethylsilyl and tetra hydropyranyl ethers, ethylene acetals and ketals with n-butyltriphenylphosphonium peroxodisulfate (BunPPh3)2S2O8

Abstract

n-Butyltriphenylphosphonium peroxodisulfate in refluxing acetonitrile transforms trimethylsilyl (TMS) and tetrahydropyranyl ethers, ethylene acetals and ketals to their corresponding carbonyl compounds in excellent yields. Selective oxidative deprotection of TMS and THP ethers in the presence of ethylene acetals (ketals) is of additional importance in this method.