Selective, convenient and efficient deprotection of trimethylsilyl and tetrahydropyranyl ethers, ethylene acetals and ketals with oxone under non-aqueous conditions

Abstract

An efficient and selective method for the deprotection of trimethylsilyl (TMS) and tetrahydropyranyl (THP) ethers, ethylene acetals and ketals to their corresponding alcohols and carbonyl compounds using oxone in refluxing acetonitrile is described. Excellent chemoselectivity of this method makes it a useful and practical procedure in organic synthesis.