Silica chloride/NaNo2 as a novel heterogeneous system for the oxidation of 1,4-dihydropyridines under mild conditions via in situ generation of NOCl

Abstract

A combination of silica chloride and sodium nitrite in the presence of wet SiO2 were used as an effective oxidizing agent for the oxidation of dihydropyridines to their corresponding pyridine derivatives under mild and heterogeneous conditions in moderate to excellent yields.