Background
Type: Article

Comparison of the Effect of a Course of Resistance and Endurance Training with Ursolic Acid Consumption on the Levels of Fetoin-A and B in the Liver Tissue of Elderly Male Diabetic Rats

Journal: Iranian Journal of Diabetes and Metabolism (23454008)Year: 2024Volume: 23Issue: Pages: 398 - 408
Bagheri L.Faramarzi M.a Farsani Z.H. Zadeh M.H.
a :University of Isfahan - IRAN(IR) - Isfahan
Language: Persian

Abstract

Background: Fetoin-A and-B are hepatokines that are related to type 2 diabetes. The aim of the present study was to investigate the effect of a period of resistance and endurance training with Ursolic acid consumption on the levels of Fetoin-A and-B in the liver tissue of elderly diabetics. Methods: Fifty six 21-month-old male diabetic rats were randomly divided into seven equal groups of control (C), Ursolic acid supplement (UA), supplement+resistance exercise (UA+R), supplement+endurance exercise (UA+E), Resistance training (R), endurance training (E) and sham group (D). Resistance training protocol with intensity of 60% MVCC, 14-20 times of ladder climbing with one minute rest between each effort and endurance training including running on Treadmill at high intensity 60-75% and low intensity 30-40% of maximum speed for five days per week for eight weeks. Supplemented groups received 500 mg/kg UA in combination with a high-fat meal. Results: Fetoin-A level was significantly decreased in UA, E, UA+E groups (p≤0.05) and only in R and UA+R groups, there was no significant decrease. Also, The amount of Fetoin-B in diabetic rats in the UA, E, R, UA+E groups decreased significantly (p≤0.05) and only in the UA+R training group there were no significant changes. The amount of Fetoin-A and Fetoin-B was significantly different between E and R and UA+R and UA+E groups (p≤0.05), which the largest decrease was in the UA+E group. supplementationConclusion: Consideringhas a more therapeuticbeneficialeffecteffectson theofhepaticexercisehepatokinestraining asof welldiabetics.as UA supplementation on hepatokines, it seems that the simultaneous application of two interventions of exercise training and UA. © 2024 Iranian Journal of Diabetes and Metabolism and Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences.