Effect of combination exercise training on sex hormone binding globulin in postmenopausal women with breast cancer

Abstract

Aim. Studies indicated that decreased sex hormone binding globulin (SHBG) can increase the risk of breast cancer and its recurrences in postmenopausal women. On the other hand, it is possible that exercise training can be positive effect on SHBG levels. Therefore, the aim of current study was to clarify the effect of combination exercise training on SHBG in postmenopausal women with breast cancer. Methods. Thus, 29 postmenopausal women with breast cancer that received surgery, chemotherapy and radiation therapy divided into two groups; intervention and control. Subjects of intervention group were performed 15 weeks combination exercise training including walking (2 sessions per week) and resistance training (2 sessions per week different from walking days). Pre and post of 15 weeks, body weight, BMI and serum SHBG levels were measured into two groups. Data were analyzed using by ANCOVA and significant levels set as P<0.05. Results. The findings of present study demonstrated that combination exercise training has significant effect on body weight, BMI and serum SHBG levels (P<0.05). In intervention group, body weight and BMI were decreased and SHBG levels were increased, after 15 weeks. Conclusion. Combination exercise training can increase serum SHBG levels in postmenopausal women with breast cancer, significantly. Because of elevated serum or plasma SHBG levels can reduce risk of breast cancer and its recurrences, combination exercise training during treatment can reduce recurrence of breast cancer by increased levels of SHBG.