The effect of continuous training on C-reactive protein of wistar 14848 rats

Abstract

Aim. This study was designed to investigate the effect of continuous training on C-reactive protein (CRP), which is the most sensitive inflammatory marker for predicting of cardiovascular disease. Methods. This study was conducted on obese, female wistar14848 rats (325.6±4.93 g and 21 months old). A pilot study was carried out to investigate the difference in CRP between the obese (226.75±5.12 g and 4 months old) and thin (168.13±5.6 g and 4 months old) young rats, and also between the obese (325.6±4.93 g and 21 months old) and thin (246.87±4.79 g and 21 months old) rats (each group included 8 rats). Then, 32 rats were divided randomly into control and experimental groups and in each group the related sub-groups were chosen randomly. An experimental training programme was carried out for five days a week at a definite treadmill speed for 12 weeks. Blood samples were drawn at three phases of pretraining, mid-training and post-training. High-sensitivity CRP was measured with an immunoturbidimetric method. Results. Repeated-measures ANOVA showed that the reduction in CRP levels was not significant (P=0/08) in the fast six weeks but CRP decreased significantly (P<0.0001) after 12 weeks. Conclusion. It can be concluded that the decline in this inflammatory marker after a period of continuous training attenuated the atherogenesis process.