An efficient, simple, and scaleable domino reaction to diverse N -(1-oxo-1H-inden-2-yl)benzamides catalyzed by HPW@nano-SiO2 under microwave irradiation

Abstract

A facile, efficient, and large-scale strategy for the synthesis of N-(1-oxo-1H-inden-2-yl)benzamide derivatives via domino reaction between aryl aldehydes, hippuric acid, and acetic anhydride catalyzed by HPW@nano-SiO 2 was accomplished under microwave irradiation. The reaction conditions are very simple and offer easy isolation of the product. Moreover, the catalyst can be re-used up to five times in 86% average yield after simple filtration. © Georg Thieme Verlag Stuttgart · New York.