Aptamer-based electrochemical biosensors

Abstract

Electrochemical biosensors play an important role in the quantification of various targets that are of utmost importance for the environmental, medical, biological, and industrial applications. For the designing and fabrication of electrochemical biosensors, the surface of electrodes should be modified with biomolecules as recognition layers that can specifically interact with these analytes. Aptamers are short synthetic oligonucleotides or peptide molecules that can bind specifically to a broad range of targets, including heavy metal ions, antibiotics, neurotransmitters, nucleotides, pesticides, drugs, proteins, biomarkers, and finally whole cells. The capability of aptamers for specifically binding to various targets makes them as highly promising candidates for the recognition layers of electrochemical biosensors. In this chapter, the recent advances in the field of “aptamer-based electrochemical biosensors” have been reviewed. © 2019 Elsevier Inc. All rights reserved.