Efficient catalytic synthesis of 2-imidazolines and bis-imidazolines with silica supported tungstosilicic acid

Abstract

A rapid and efficient preparation of 2-imidazolines and bis-imidazolines by the reaction of ethylenediamine or 1,2-propanediamine with nitriles in the presence of catalytic amounts of tungstosilicic acid supported on SiO 2 under reflux condition, is reported. The advantages of this procedure are moderate reaction times, good to high yields and the ability to carry out the large scale reactions. © ARKAT USA, Inc.