POLAROGRAPHIC AND COLORIMETRIC DETERMINATION OF DACARBAZINE

Abstract

The polarographic method is used for the identification and determination of Dacarbazine (1) [an antineoplastic drug]. The results indicate that 1 can be identified and determined as the pure compound or as a constituent of galenic preparations at concentrations between 10-3 and 10-5 mol/l. The N = N-group, which is reduced by the addition of 4 electrons and 4 protons, is polarographically active.