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Jalilian, A.R., Fateh, B., Ghergherehchi, M., Karimian, A.R., Moradkhani, S., Kamali-dehghan, M., Tabeie, F.
Nukleonika (15085791)50(4)pp. 143-148
Bleomycin (BLM), labeled with radioisotopes, is widely used in therapy and diagnosis. In this study, BLM was labeled with 62Zn for oncologic PET studies. The complex was obtained at pH = 2 in saline at 90°C in 25 min. Radio-TLC showed an overall radiochemical yield of 95-97% (radiochemical purity > 97%). Stability of complex was checked in vitro in mice and human plasma/urine. Preliminary in vivo studies were performed to determine complex stability and distribution of 62Zn BLM in normal and fibrosarcoma-bearing mice. 62Zn BLM accumulated significantly in induced fibrosarcoma tumors in mice according to biodistribution/imaging studies. 62Zn BLM can be used in PET oncology studies due to its suitable physicochemical properties as a diagnostic complex in vitro and in vivo. Further studies should be performed for evaluation of the complex behavior in larger mammals.
Annals of DAAAM and Proceedings of the International DAAAM Symposium (17269679)pp. 345-346
One of the problems in middle size robot soccer, which also can be applied to scanner robots routing in unpredictable environments, is leading passing among robots that comprises choosing the best team-mate to receive the ball without any need to explicit communication among robots. In this paper we have developed an algorithm based on Perceptron neural network for this problem which determines the best passing angle based on the topological data of the play field (i.e. position of robots). With a modification to Perceptron structure and proper data presentation approach a considerable improvement in solution performance has been achieved.
Jalilian, A.R., Akhlaghi, M., Saddadi, F., Mirzaii, M., Karimian, A.R., Pouladi m., , Yari kamrani y., , Moradkhani, S., Shadanpour n.,
Iranian Journal Of Nuclear Medicine (20082509)14(26)
Introduction: [18F]-6-thia-14-fluoro-heptadecanoic acid 3b, a free fatty acid, has been used in myocardial PET imaging. In order to establish an automated synthesis module for routine production in the country, a study performed for optimization of the production conditions as well as making modifications. Methods: [18F] Benzyl-14-Fluoro-6-thia-heptadecanoate 2b was prepared in no-carrier-added (n.c.a) form from Benzyl-14-tosyloxy-6-thia- heptadecanoate 1 in one step at 90°C in Kryptofix2.2.2/[18F] and acetonitrile as the solvent followed by Silica column chromatography. The radiolabeled ester 2 was then hydrolyzed to yield [18F]-6-thia-14- fluoro-heptadecanoic 3b. The final solution was concentrated using C 18 SPE system and administered to normal rats for biodistribution as well as co-incidence imaging studies. Results: The synthesis took 15 min with overall radiochemical yield of 15-25% (EOS) and chemical-radiochemical purity more than 94%. Automation was performed using a two-pot synthesis. The best imaging time was shown to be 140-180 minutes post injection. Conclusions: Using this procedure a fast, reliable, automated synthesis for the cordial PET tracer, i.e. [18F]-FTHA can be obtained without HPLC purification step.
Jalilian, A.R., Hosseini, M.A., Karimian, A.R., Saddadi, F., Sadeghi m., M.
Nukleonika (15085791)51(4)pp. 203-208
Thallium-201 (T1/2 = 3.04 days) in Tl+ form was converted to Tl3+ cation in presence of O3 in 6 M HCl controlled by RTLC/gel electrophoresis methods. The final evaporated activity was reacted with vancomycin (VAN) in water to yield [201Tl](III)VAN. The best results were obtained at room temperature in water after 30 min with a radiochemical yield > 99%, after mixing the reactants followed by SPE purification using Si Sep-Pak. The studies showed that thallic ion is mostly incorporated into vancomycin with a radiochemical purity of more than 98 ± 1% by RTLC. A specific activity of about 4.14 × 1010 Bq/mmol was obtained. Radiochemical purity and stability of 201Tl-VAN in the preparation and in presence of human serum was determined up to 5.5 days. Biodistribution study of 201Tl(III)-vancomycin in normal rats was performed up to 52 h.
Rowshanfarzad, P., Jalilian, A.R., Kiyomarsi, M., Sabet, M., Karimian, A.R., Moradkhani, S., Mirzaii, M.
Nukleonika (15085791)51(4)pp. 209-215
Rubidium-82m was prepared via 15.4 MeV proton irradiation of a krypton-82 gaseous target (30% enrichment). Washing the target chamber with hot water yielded a Rb-82m containing solution, which was further purified using short column chromatography in order to remove organic/inorganic impurities. The flowthrough was formulated in normal saline for injection. Radionuclide, radiochemical and chemical purity tests were performed prior to administration to rats for imaging (radiochemical yield: 95-97%, radiochemical purity > 97%). Preliminary dual-head coincidence studies were performed to determine the distribution of [82mRb]Rb in normal rats. For biodistribution studies, Rb-81 was injected to rats and tracer accumulation in heart, GI and bladder was determined after sacrification in time intervals. A yield of 1.3 GBq at EOB, 235.7 MBq/μAh was obtained.
Jamshidi, N., Rostami, M., Arshi, A.R., Salaami, F.
pp. 50-55
In this paper the weightlifters snatch optimization will be studied. The biomechanical model is used for two-dimensional modeling on sagittal plan. It is estimated by an error back propagation network, in a way that inputs of this network are kinematics data such as absolute angular velocity, relative angles of joints, of different body segments and output is created torque at the joints. Finally the neural network model has been optimized for minimizing the created torque at the joints.
International Journal of Advanced Robotic Systems (17298806)4(1)pp. 93-101
Multi-Agent systems have generated lots of excitement in recent years because of its promise as a new paradigm for conceptualizing, designing, and implementing software systems. One of the most important aspects of agent design in AI is the way agent acts or responds to the environment that the agent is acting upon. An effective action selection and behavioral method gives a powerful advantage in overall agent performance. We define a new method of action selection based on probability/priority models, we thereby introduce two efficient ways to determine probabilities using neuro-fuzzy systems and bidirectional neural networks and a new priority based system which maps the human knowledge to the action selection method. Furthermore, a behavior model is introduced to make the model more flexible.
The main aim of this work is to investigate the use of new lanthanum bromide (LaBr3) in whole body PET (WB-PET) scanners and to compare the obtained results with those for BGO and LSO crystals which are currently used in conventional and dedicated PET systems. Our results show that there is a gain in noise effective count rate (NECR) arising from the reduced scatter and random fractions in a LaBr3 scanner. The spatial resolution of the WB-PET with LaBr3 is slightly worse than the LSO and BGO crystals because of its low density and effective atomic number. But our study showed the increased NECR, excellent energy resolution and low decay time of LaBr 3 which promise a significant improvement in WB-PET performances especially for narrow coincidence windows.
Jamshidi, N., Rostami, M., Najarian, S., Menhaj, M.B., Saadatnia, M., Firooz, S.
Singapore Medical Journal (00375675)50(4)pp. 412-417
Introduction: This paper deals with the dynamic modelling of human walking. The main focus of this research was to optimise the function of the orthosis in patients with neuropathic feet, based on the kinematics data from different categories of neuropathic patients. Methods: The patient's body on the sagittal plane was modelled for calculating the torques generated in joints. The kinematics data required for mathematical modelling of the patients were obtained from the films of patients captured by high speed camera, and then the films were analysed through a motion analysis software. An inverse dynamic model was used for estimating the spring coefficient. Results: In our dynamic model, the role of muscles was substituted by adding a spring-damper between the shank and ankle that could compensate for their weakness by designing ankle-foot orthoses based on the kinematics data obtained from the patients. The torque generated in the ankle was varied by changing the spring constant. Therefore, it was possible to decrease the torque generated in muscles which could lead to the design of more comfortable and efficient orthoses. Conclusion: In this research, unlike previous research activities, instead of studying the abnormal gait or modelling the ankle-foot orthosis separately, the function of the ankle-foot orthosis on the abnormal gait has been quantitatively improved through a correction of the torque.
Moghaddam, N.M., Karimian, A.R., Mostajaboddavati, S.M., Vondervoort, E., Sossi, V.
Nukleonika (15085791)54(1)pp. 33-38
Preliminary design of a spherical brain PET (SBPET) using liquid xenon (LXe) as detector is considered in this research work. The major advantage of a spherical design is the large solid angle of acceptance which improves the sensitivity and increases signal-to-noise ratio (SNR) of the image. The use of a liquid active medium enabled us to design a spherical detector. LXe, due to the intrinsic physical properties, is an excellent liquid medium for accurate tracking of gamma rays in the relevant energy range. The performance of SBPET was evaluated by Monte Carlo simulation tools (GATE) and compared to ECAT HRRT. The numerical results showed the SBPET has a sensitivity of 1.14% and spatial resolution of ~2.7 mm FWHM which is superior to ECAT HRRT especially at high-count rates.
