Articles
Ghahramani Almanghadim H.,
Karimi, B.,
Valizadeh S.,
Ghaedi, K.,
Forouzan, A.R.,
Akbari s., S.,
Sheikhbahaei, M.,
Maimani h.r., Non-coding RNA Research (24680540)pp. 70-90
Recently, the various regulative functions of long non-coding RNAs (LncRNAs) have been well determined. Recently, the vital role of LncRNAs as gene regulators has been identified in the immune system, especially in the inflammatory response. All cells of the immune system are governed by a complex and ever-changing gene expression program that is regulated through both transcriptional and post-transcriptional processes. LncRNAs regulate gene expression within the cell nucleus by influencing transcription or through post-transcriptional processes that affect the splicing, stability, or translation of messenger RNAs (mRNAs). Recent studies in immunology have revealed substantial alterations in the expression of lncRNAs during the activation of the innate immune system as well as the development, differentiation, and activation of T cells. These lncRNAs regulate key aspects of immune function, including the manufacturing of inflammatory molecules, cellular distinction, and cell movement. They do this by modulating protein-protein interactions or through base pairing with RNA and DNA. Here we review the current understanding of the mechanism of action of lncRNAs as novel immune-related regulators and their impact on physiological and pathological processes related to the immune system, including autoimmune diseases. We also highlight the emerging pattern of gene expression control in important research areas at the intersection between immunology and lncRNA biology. © 2024 The Authors
Janatyan, N.,
Dezhtaherian, M.,
Esteki M.,
Forouzan, A.R.,
Janbaz, S.,
Oboudi, M.R. International Journal of Quality and Reliability Management (0265671X)pp. 401-408
Purpose: Companies look for their customers’ requirements (CRs) due to the importance of providing customer satisfaction in creating a competitive advantage. The purpose of this study is to introduce and categorize methods of prioritizing CRs based on company-oriented to customer-oriented approaches spectrum. Design/methodology/approach: Three methods, i.e. traditional FMEA, the Madzik and Kormanec method and the FAHP-FTOPSIS method, have been used to prioritize CRs in an auto-parts company. In this study, the most important CRs were identified and prioritized based on the opinions of senior managers to increase customer satisfaction in an auto-parts company. So, the 10 CRs were prioritized via customer-oriented and company-oriented approaches by considering the opinions of the managers of the company. Requirement curves were depicted with the help of average start and endpoint for each CR. Moreover, Risk Priority Number (RPN) and values of the effort and effect indexes were calculated using customer orientation and FAHP-FTOPSIS methods. Findings: The results of this research showed that CR1 (High quality of the part) is in first place of priority in traditional FMEA, CR3 (High quality of lining of the part) is in the first priority in the FAHP-FTOPSIS method and CR10 (After-sales service and warranty) is the most important in the Madzik and Kormanec method. The difference in results is because of the difference in their approach to data collection from customers or managers of the company. Originality/value: The originality of this study is to consider the methods of prioritizing the CRs of products due to the spectrum of company-oriented to customer-oriented approaches. © 2025, Emerald Publishing Limited.
IET Communications (17518628)19(1)
In this paper, we investigate optimal receiver filter design with respect to shot noise in both non-coherent and coherent fibre optic communication systems. We derive analytical expressions for the moment-generating function of filter output and the signal-to-shot noise power ratio (SSNR) for intensity modulation direct detection (IM/DD) and phase diversity homodyne (PDH) optical fibre communication systems, with arbitrary waveform and receiver filter considerations in the presence of shot noise. Closed-form formulas are provided for the receiver filter structures that maximise the SSNR. The performance of SSNR is evaluated using return-to-zero (RZ) coding with rectangular and Gaussian pulse shapes across various receiver filter structures, including the ideal integrator, the RC model, and the matched filter. Our results indicate that the integrator, or its variations, is either optimal or near-optimal for diverse IM/DD systems. However, matched filtering to the received pulse power becomes superior when dark current or d.c. bias power is prominent. For coherent PDH systems, matched filtering to the complex received pulse amplitude approaches near-optimal performance provided the local oscillator (LO) power significantly exceeds the received signal power. When the LO power is much greater than the signal power, such systems can achieve double the SSNR of IM/DD systems, equivalent to twice the number of converted photoelectrons per symbol, thus nearing the quantum-limit performance considering the photodetector quantum efficiency. © 2025 The Author(s). IET Communications published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology.
