A Stereoselective three-component reaction:The facile synthesis of fluorinated tetrahydropyrimido[1,2-b]benzothiazoles

Abstract

A one-pot, catalyst- and solvent-free approach has been developed for the stereoselective synthesis of fluorinated tetrahydropyrimido[1,2-b] benzothiazoles. The three-component condensation reaction of an aldehyde and a trifluoromethyl β- dicarbonyl compound in the presence of 2-aminobenzothizole occurs in high yields at 90 °C.