Type: Article

Efficient one-pot synthesis of new fused pyridines and bis-pyridines catalyzed by triazine diphosphonium hydrogen sulfate ionic liquid supported on functionalized nano-silica

Journal: Tetrahedron Letters (00404039)Year: 25 May 2016Volume: 57Issue: Pages: 2294 - 2297

Rahmani F.Mohammadpoor Baltork I.^a Khosropour A.R.Moghadam M.^aTangestaninejad S.^aMirkhani V.^a

a :University of Isfahan - IRAN(IR) - Isfahan

DOI:10.1016/j.tetlet.2016.04.053Language: English

Abstract

The efficient synthesis of novel fused pyridines via the three component condensation of aldehydes, kojic acid, and 6-amino-1,3-dimethyluracil, catalyzed by the ionic liquid aminopropyl-1,3,5-triazine-2,4-diphosphonium hydrogen sulfate supported on functionalized nano-silica, under solvent-free conditions is reported. Additionally, bis-derivatives of these compounds were smoothly synthesized from dialdehydes. This method has the advantages of mild conditions, high yields, short reaction times, easy work-up, and being environmentally friendly. Moreover, the catalyst can be easily separated from the reaction mixture, recycled, and reused several times without a noticeable decrease in catalytic activity. © 2016 Elsevier Ltd. All rights reserved.