Type: Article

Regioselective multi-component synthesis of 1H-pyrazolo[3,4-d]pyrimidine- 6(7H)-thiones

Journal: Molecular Diversity (1573501X)Year: August 2012Volume: 16Issue: Pages: 591 - 600

Safaei S.Mohammadpoor Baltork I.^a Khosropour A.R.Moghadam M.^aTangestaninejad S.^aMirkhani V.^a

a :University of Isfahan - IRAN(IR) - Isfahan

DOI:10.1007/s11030-012-9391-0Language: English

Abstract

A variety of pyrazolo[3,4-d]pyrimidine-6(7H)-thione derivatives were easily synthesized with a novel, simple, efficient, and regioselective method via three-component condensation reaction of 5-methyl-1H-pyrazol-3-amine, arylisothiocyanates, and aldehydes in the presence of catalytic amount of p-toluenesulfonic acid (p-TSA) in 1-butyl-3-methylimidazolium bromide ionic liquidwith excellent yields and short reaction times. © Springer Science+Business Media B.V. 2012.