Wheel-shaped copper containing polyoxotungstate as an efficient catalyst in the three-component synthesis of 1,2,3-triazoles

Abstract

Wheel-shaped polyoxotungstate [Cu20Cl(OH)24(H2O)12(P8W48O184)]25- (Cu20 POM) was used as an efficient catalyst for the preparation of triazoles from the corresponding alkyl halides, sodium azide, and alkynes. In this click reaction, the three-component synthesis of 1,2,3-triazoles was performed under mild reaction conditions at room temperature and high to excellent yields were obtained. The isolation and purification processing of organic azides were avoided in this procedure, as they were prepared in situ. © The Royal Society of Chemistry 2016.