Type: Article
A one-pot four-component synthesis of N-arylidene-2-aryl-imidazo[1,2-a] azin-3-amines
Journal: Tetrahedron Letters (00404039)Year: 2014/07/16Volume: 55Issue: 29Pages: 3840 - 3843
DOI:10.1016/j.tetlet.2014.03.098Language: English
Abstract
N-Arylidene-2-aryl-imidazo[1,2-a]azin-3-amines were synthesized via a one-pot, four-component condensation reaction using a 2-aminoazine, toluene-4-sulfonylmethyl isocyanide (TsCH2NC), and two equivalents of readily available aromatic aldehydes. The reaction was performed in diethyl ether as the solvent, with p-toluenesulfonic acid (p-TSA) as the catalyst at reflux temperature.
Author Keywords
Imidazo[1,2-a]pyrazinesImidazo[1,2-a]pyridineMulti-component reactions
Other Keywords
2 aminopyridinealdehydeamineetherimidazolen arylidene 2 aryl imidazo[1,2 alpha]azin 3 aminesulfonic acid derivativetoluenetoluene 4 sulfonylmethyl isocyanidetoluenesulfonic acidunclassified drugaldehyde derivativen arylidene 2 aryl imidazo[1,2 a]azin 3 aminesolventtoluenesulfonic acid derivativearticlecatalystone pot synthesispolymerizationtemperaturecarbon nuclear magnetic resonancecombinatorial chemistryproton nuclear magnetic resonance