Type: Article
A one-pot, three-component synthesis of spiro[indoline-isoxazolo[40,30:5,6] pyrido [2,3-d]pyrimidine]triones in water
Journal: Tetrahedron (00404020)Year: 2012/10/07Volume: 68Issue: 40Pages: 8472 - 8479
Rahmati A.a Khalesi Z.
DOI:10.1016/j.tet.2012.07.073Language: English
Abstract
A one-pot, three-component condensation reaction of an isatin, isoxazole, and barbituric acid in water to give spirooxindoles in high yields, at 70°C temperature, using a catalytic amount of p-toluene sulfonic acid, is described. © 2012 Elsevier Ltd. All rights reserved.