Aluminum dodecatungstophosphate promoted synthesis of 1,5-benzodiazepine derivatives under solvent-free conditions

Abstract

Solid heteropoly acids (AITP and AIMP) are easily used as efficient catalyst for conversion of o-phenylenediamines and ketones to their corresponding 2,3-dihydro-1H-1,5-benzodiazepines at room temperature under solvent-free conditions. The method is an easy, rapid, and high yielding reaction for the synthesis of 1,5-benzodiazepine derivatives and is applicable to both cyclic or acyclic ketones without significant difference. © 2007 The Japan Institute of Heterocyclic Chemistry.