Type: Article
An efficient solvent-free synthesis of 2-(alkylamino)-2-oxo-1-arylethyl-6,12-dioxo-6,12-dihydroindolo[1,2-b]isoquinoline-11-carboxylate derivatives via four-component reaction
Journal: Molecular Diversity (13811991)Year: 2019/11/01Volume: 23Issue: 4Pages: 1011 - 1018
Kenarkoohi T.Rahmati A.a
DOI:10.1007/s11030-018-09911-6Language: English
Abstract
Abstract: A one-pot approach for the synthesis of a new series of 2-(alkylamino)-2-oxo-1-arylethyl-6,12-dioxo-6,12-dihydroindolo[1,2-b]isoquinoline-11-carboxylate derivatives via a four-component reaction using isatin, homophthalic anhydride, cyclohexyl isocyanide and an aldehyde is described. This method has several advantages such as being catalyst- and solvent-free reaction and a high-efficiency process with high to excellent yields. Graphical abstract: [Figure not available: see fulltext.]. © 2019, Springer Nature Switzerland AG.
Author Keywords
DihydroindoleIndoloisoquinolineIsocyanideIsoquinolinePasserini-like reaction
Other Keywords
Carboxylic AcidsGreen Chemistry TechnologyIsoquinolines(cyclohexylcarbamoyl)(2 methoxyphenyl) methyl 6,12 dihydro 6,12 dioxoindolo[1,2 b]isoquinoline 11 carboxylate(cyclohexylcarbamoyl)(3 methoxyphenyl) methyl 6,12 dihydro 6,12 dioxoindolo[1,2 b]isoquinoline 11 carboxylate(cyclohexylcarbamoyl)(4 methoxyphenyl) methyl 6,12 dihydro 2 methyl 6,12 dioxoindolo[1,2 b] isoquinoline 11 carboxylate(cyclohexylcarbamoyl)(4 methoxyphenyl) methyl 6,12 dihydro 6,12 dioxoindolo[1,2 b]isoquinoline 11 carboxylate(cyclohexylcarbamoyl)(4 tolyl)methyl 6,12 dihydro 6,12 dioxoindolo[ 1,2 b]isoquinoline 11 carboxylate(cyclohexylcarbamoyl)(phenyl) methyl 6,12 dihydro 6,12 dioxoindolo[1,2 b] isoquinoline 11 carboxylate(cyclohexylcarbamoyl)(phenyl)methyl 6,12 dihydro 2 methyl 6,12 dioxoindolo[ 1,2 b]isoquinoline 11 carboxylate2 (alkylmino) 2 oxo 1 arylethyl 6,12 dioxo 6,12 dihydroindolo[1,2 b]isoquinoline 11 carboxylate derivative2(cyclohexylcarbamoyl)(2,3 dimethoxyphenyl) methyl 6,12 dihydro 6,12 dioxoindolo[1,2 b]isoquinoline 11 carboxylatealdehydecarboxyl groupcarboxylic acid derivativecyanamidecyclohexyl isocyanidehomophthalic anhydrideisatinunclassified drugcarboxylic acidisoquinoline derivativeArticlecatalystchemical reactionchemical structureone pot synthesispolymerizationpriority journalprocess optimizationgreen chemistrysynthesis