Type: Article
Clean synthesis in water: uncatalyzed three-component condensation reaction of 3-amino-1,2,4-triazole or 2-aminobenzimidazole with aldehyde in the presence of activated CH-acids
Journal: QSAR and Combinatorial Science (1611020X)Year: 2007/09/01Volume: 26Issue: 9Pages: 973 - 979
DOI:10.1002/qsar.200620024Language: English
Abstract
An environment-friendly three-component condensation of 3-amino-1,2,4-triazole or 2-aminobenzimidazole, an aldehyde and activated CH-acid such as β-dicarbonyl compounds and malononitrile, affords the corresponding pyrimidine-based annulated di- and triheterocyclic ring systems. Reactions are performed in water, without the addition of catalyst, and in good yield. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
Author Keywords
2-Aminobenzimidazole3-Amino-1,2,4-triazoleCH-acidThree-component reactionWaterAldehydesCondensation reactions
Other Keywords
AldehydesCondensation reactionsaldehydebenzimidazole derivativetriazole derivativewater2-aminobenzimidazole3-Amino-13-amino-1,2,4-triazoleAminobenzimidazolesCH-acidClean synthesisDicarbonyl compoundsEnvironment friendlyThree component reactionsThree-componentarticlechemical reactionchemical structureheat treatmentmolecular interactionpolymerizationpriority journalreaction analysisstructure analysisCondensation