Background
Type: Article

Isolation, characterization, and genomic analysis of three novel Herelleviridae family lytic bacteriophages against uropathogenic isolates of Staphylococcus saprophyticus

Journal: Virology Journal (1743422X)Year: 2025Volume: Issue: 1Pages: 1358 - 1366
Shirzad-Aski H. Yazdi M. Mohebbi A. Rafiee M. Soleimani-Delfan A. Tabarraei A. Ghaemi E.A.Asadi P.Abbasi Jondani J.Abbasi Jondani J.Asadi P.Abbasi Jondani J.Rahrovi Dastjerdi A.aTaymouri, Somayeh Yazdkhasti F. Yazdkhasti F.Taymouri, Somayeh Yazdkhasti F. Saadatseresht M.Foroghi D.a Khodarahmi G. Abedi A. Khodarahmi G. Abedi A. Varshosaz M.Kiani G.H. Jalali H. Jalali H. Sadeghi-Aliabadi H. Dinari M. Dinari M.
a :University of Isfahan - IRAN(IR) - Isfahan
DOI:10.1186/s12985-025-02710-0Language: English

Abstract

Background: Staphylococcus saprophyticus (S. saprophyticus) is the second most prevalent etiological agent of urinary tract infections (UTIs) in young women. However, there is a paucity of data regarding its bacteriophage (phage). Therefore, this study was conducted to isolate and identify new lytic phages from municipal wastewater with the objective of increasing knowledge about phages and their genomes. Methods: A total of 11 clinical isolates of S. saprophyticus and 30 wastewater samples were used to isolate three lytic phages (vB_SsapH-Golestan-100, vB_SsapH-Golestan101-M, and vB_SsapH-Golestan-105-M). The morphology, behavioral characteristics, and complete DNA genomes of these phages were analyzed. Results: The microscopic images of the phages revealed that the sizes of their heads and tail lengths fell within the ranges of 90–111 nm and 234–266 nm, respectively. All phages exhibited high adsorption rates (99.5% in 15 min) and burst sizes (150–210 PFU per infected cell), with a potential for a narrow host range. Genomic analysis of Staphylococcus phages indicated a size of 136,433 base pairs (bp) with a guanine-cytosine (GC) content of 33.7% and 192 open reading frames (ORFs) for vB_SsapH-Golestan-100, 144,081 bp with a GC content of 29.6% and 205 ORFs for vB_SsapH-Golestan101-M, and 142,199 bp with a GC content of 30.6% and 203 ORFs for vB_SsapH-Golestan-105-M. A bioinformatics analysis indicated that all three phages belong to the Twortvirinae subfamily of Herelleviridae. Among the three phages, vB_SsapH-Golestan-100 exhibited the least similarity to previously known phages, with less than 21% similarity with its closest counterparts in genomic databases. Conclusions: This study identified new phages that have the ability to destroy a broad range of S. saprophyticus isolates and may potentially be classified as a new genus and species within the Herelleviridae family in future studies. © The Author(s) 2025.

Author Keywords

HerelleviridaeLytic bacteriophageStaphylococcus saprophyticusUrinary tract infectionWhole genome sequencingcovalent organic frameworksdrug deliveryimatinibporous materialssynthesisCompulsive checkingMemoryMemory accuracyMemory confidenceMeta-AnalysisOCDCompulsive checkingMemoryMemory accuracyMemory confidenceMeta-AnalysisOCDcovalent organic frameworksdrug deliveryimatinibporous materialssynthesisCompulsive checkingMemoryMemory accuracyMemory confidenceMeta-AnalysisOCDElectronic PropertiesFirst-Principles CalculationsFull-Heusler CompoundsMaterial StabilityMechanical Propertiescovalent organic frameworksdrug deliveryimatinibporous materialssynthesisAnderson type manganese polyoxomolybdate (POMo)Anticancer agentApoptosisEudesmic acid (EU)Organo-conjugateQuantum chemical calculationsAnticancer agentsImidazopyridine ringMolecular dockingOne-pot synthesisApoptosis assayCisplatin resistanceK562 cellsMTT assayPalladacyclic complexbiological activitycancerindolesynthesis designthiosemicarbazone2D feature3D-QSABayesian modelDockingExtended-connectivity fingerprintsPharmacophore modelingTubulin inhibitorVirtual screeningApiaceaecytotoxicityessential oilherbal medicineKelussia odoratissimahybrid compositeinsulinintercalationporous coatingZirconium phosphatePaclitaxelPharmacokineticsPolymeric micelleExplant cultureHumanMesenchymal stem cellsUmbilical cordWharton’s jellyDoxorubicinFolate targeted micellesKG-1 cellsβ-Cyclodextrin3-hydroxypyridin-4-onesHeLa and K562 cellsIron chelating agentsLipophilicityAntitumor activityBenzylamineBridged biphosphinicCrystal structureCyclopalladated complexes1,4-DihydropyridinesConformational analysisDensity functional theorySemi-empirical1,4-Dihydropyridine-3,5-dicarbamoxamide derivativesAntitubercular activityMycobacterium tuberculosis4-ChlorobiphenylCatecholsDihyroxylated metabolitesGlutathioneHepatocytesOxidative stressPCBsPolychlorinated biphenylsAmetantrone derivativesAnthraquinone synthesisCancer cellsAltmetricBibliometricsCardiovascular DiseasesPublicationsScientometricsSocial MediaTelemedicineTopic modeling Text miningCo-occurrence analysisCo-word analysisHealth communicationStrategic chartVocabulary analysisCo-Occurrence WordHierarchical Agglomerative Clustering (HAC)Hierarchical ClusteringInternet of Things (IoT)Thematic AnalysisWeb of Science (WoS)Disabilityoverviewsystematic reviewviolenceblended familiesdivorcequalitative studyremarriagesexual dynamicsHealth of the original familyMarital commitmentSelf-compassionBaroclinicMesoscale eddyNumerical modelingPersian GulfThermohaline fluxesWind stressSeasonal componentSpectral analysisTime seriesTrend analysisAtmospheric pressureLagSingular value decompositionCayley graphCospectral graphSpectrum of a graphAlternating groupsFinite simple groupsNon-commuting graphGeneral linear groupSpecial linear groupCompulsive checkingMemoryMemory accuracyMemory confidenceMeta-AnalysisOCDMarital enrichment programMarital relationshipMarital therapyMarriageQualitative researchMulti-shotscannersPhotometric stereoPoint cloud simplificationcovalent organic frameworksdrug deliveryimatinibporous materialssynthesisAnderson type manganese polyoxomolybdate (POMo)Anticancer agentApoptosisEudesmic acid (EU)Organo-conjugateQuantum chemical calculationsAnticancer agentsImidazopyridine ringMolecular dockingOne-pot synthesisApoptosis assayCisplatin resistanceK562 cellsMTT assayPalladacyclic complexbiological activitycancerindolesynthesis designthiosemicarbazone2D feature3D-QSABayesian modelDockingExtended-connectivity fingerprintsPharmacophore modelingTubulin inhibitorVirtual screeningApiaceaecytotoxicityessential oilherbal medicineKelussia odoratissimahybrid compositeinsulinintercalationporous coatingZirconium phosphatePaclitaxelPharmacokineticsPolymeric micelleExplant cultureHumanMesenchymal stem cellsUmbilical cordWharton’s jellyDoxorubicinFolate targeted micellesKG-1 cellsβ-Cyclodextrin3-hydroxypyridin-4-onesHeLa and K562 cellsIron chelating agentsLipophilicityAntitumor activityBenzylamineBridged biphosphinicCrystal structureCyclopalladated complexes1,4-DihydropyridinesConformational analysisDensity functional theorySemi-empirical1,4-Dihydropyridine-3,5-dicarbamoxamide derivativesAntitubercular activityMycobacterium tuberculosis4-ChlorobiphenylCatecholsDihyroxylated metabolitesGlutathioneHepatocytesOxidative stressPCBsPolychlorinated biphenylsAmetantrone derivativesAnthraquinone synthesisCancer cellsAltmetricBibliometricsCardiovascular DiseasesPublicationsScientometricsSocial MediaTelemedicineTopic modeling Text miningCo-occurrence analysisCo-word analysisHealth communicationStrategic chartVocabulary analysisCo-Occurrence WordHierarchical Agglomerative Clustering (HAC)Hierarchical ClusteringInternet of Things (IoT)Thematic AnalysisWeb of Science (WoS)Disabilityoverviewsystematic reviewviolenceblended familiesdivorcequalitative studyremarriagesexual dynamicsHealth of the original familyMarital commitmentSelf-compassionBaroclinicMesoscale eddyNumerical modelingPersian GulfThermohaline fluxesWind stressSeasonal componentSpectral analysisTime seriesTrend analysisAtmospheric pressureLagSingular value decompositionCayley graphCospectral graphSpectrum of a graphAlternating groupsFinite simple groupsNon-commuting graphGeneral linear groupSpecial linear groupCompulsive checkingMemoryMemory accuracyMemory confidenceMeta-AnalysisOCDMarital enrichment programMarital relationshipMarital therapyMarriageQualitative researchMulti-shotscannersPhotometric stereoPoint cloud simplificationFlash pointGasolineNanoparticleOctane numberOptimizationOxygen-containing additivesDegradationGas refinery effluentSunlightZnO/TiO2-AC photocatalystadsorptiondecorated graphendensity of statesGap energyAcrylonitrile productionEconomic considerationsPolypropyleneSimulation(1-x-y)LiNi0.7Co0.3O2Li1.167Ni0.116Co0.717Mn0.167O2Li2MnO3LiCoO2Lithium ion batteryMole-fractionsSol–gel methodStoichiometric weightsCharacterizations of inner product spacesDunkl-Williams inequalityInner product spaceCosmetic ProductsImpulsive Buying BehaviorLuxury ProductsPerceived Service QualityPurchase Intentiondeconstructabilityflexural resistance factorreliability analysisshear connectorsustainable constructionComposite beamDeconstructable boltFinite element modelingMonte Carlo simulationProbabilistic analysisSpring modelFE modelingHSFGB shear connectorpartial factorpush-out teststatistical analysisComposite jointsDeconstructableFinite element modelFriction-grip boltHigh strength steelSustainableAnt colony optimizationNon-linear optimizationSteel-making-continuous casting schedulingJealousyPat hemic dimension of discourseSadegh HedayatSemiotics of passion“forgiveness”Discursive semioticsEmotional and esthetic dimensionsManzoome Be Shahriar of NimaPerceptive dimensionFlysch zoneGraphoglyptidsMakranMiocene ichnofaunaNereites ichnofaciesTrace fossilCarbonate rampGeochemistryIranMicrofaciesMiddle–Late DevonianSequence stratigraphyCompostEcological riskEmerging contaminantsMicroplasticPolymer compositionSoil pollutantsAlternative energy sourceCement industriesDeveloping countriesMechanical and biological treatment plantMunicipal solid waste rejected fractionsRefused derived fuelAghajari fieldAsmari Formationcurvature analysisDezful Embaymentfracture analysis.geometrical analysisZagros fold-and-thrust beltCode-division multiple-accessindoor radio communicationinterference suppressionorthogonal spreading codesspectrally-encoded CDMAspread-time CDMAComplexity reductionCoordinated DSLCrosstalk cancellationDigital subscriber lines (DSL)Far-end crosstalk (FEXT)Partial crosstalk cancellationVector codingartcomplementary and alternative therapies (CAT)Multiple sclerosis (MS)narrative inquirypatient quality of lifeArtificial neural networksCSR particlesEpoxy adhesiveLap shear strengthSynergistic effectZinc oxide nanoparticlesAcrylicEncapsulationMiniemulsion polymerizationModified SiO2Nanocompositeblock theoryEngineering geologyfailure mechanismsnatural slopeDistal femoral strengthFailure analysisFinite element methodIn-vitro compressive testsNon-homogeneityNon-linear behaviorQuantitative computed tomographyEmulsifierGlass fiberMicrosurfacing mixturesPolypropylene fiberStabilizersAcid gasAir cleaningAir pollutionGas absorptionScreeningSulfur dioxideSustainable solventAccessibilityIonic liquidLignocelluloseLow-intensity sonicationSimons’ stainBioethanolCrystallinityPretreatmentSimons' staindutyKantmaximMoral valuemotivationoverdeterminationAnd phrasesQuasi-Frobenius ringRight Artinian ringRight pure-injective ringBalanced scorecardScientific mapSocial network analysisWeb of science databaseData miningText mining

Other Keywords

DNA, ViralFemaleGenome, ViralGenomicsHost SpecificityHumansPhylogenySequence Analysis, DNAStaphylococcal InfectionsStaphylococcus PhagesStaphylococcus saprophyticusUrinary Tract InfectionsWastewatervirus DNAadsorptionArticlebacterial strainbacteriophagebacterium isolatebacterium isolationbioinformaticsgene sequencegenetic analysisgenome analysishost rangenonhumannucleotide sequencephenotypephylogenyplasmidproteomicsStaphylococcus saprophyticustransmission electron microscopyurinary tract infectionvirus characterizationvirus isolationwhole genome sequencingclassificationDNA sequencingfemalegeneticsgenomicshost rangehumanisolation and purificationmicrobiologyphylogenyStaphylococcus infectionStaphylococcus phagevirologyvirus genomewastewaterCancer cellsCell cultureCellsControlled drug deliveryDiseasesDrug productsNanostructured materialsPorous materialsTargeted drug deliveryAnti-cancer drug deliveryCovalent organic frameworksImatinibMorphology characterizationsNano scaleSolvothermal reactionsStructure and morphologyStructure characterizationSustained releaseSynthesisedBiocompatibilityHumansMemoryObsessive-Compulsive Disorderdeteriorationeffect sizehumanmeta analysisoutcome variablepublication biasresponsibilityreviewsystematic reviewcomplicationobsessive compulsive disorderHumansMemoryObsessive-Compulsive Disorderdeteriorationeffect sizehumanmeta analysisoutcome variablepublication biasresponsibilityreviewsystematic reviewcomplicationobsessive compulsive disorderCancer cellsCell cultureCellsControlled drug deliveryDiseasesDrug productsNanostructured materialsPorous materialsTargeted drug deliveryAnti-cancer drug deliveryCovalent organic frameworksImatinibMorphology characterizationsNano scaleSolvothermal reactionsStructure and morphologyStructure characterizationSustained releaseSynthesisedBiocompatibilityHumansMemoryObsessive-Compulsive Disorderdeteriorationeffect sizehumanmeta analysisoutcome variablepublication biasresponsibilityreviewsystematic reviewcomplicationobsessive compulsive disorderGadolinium compoundsGermanium compoundsHafnium compoundsLithium compoundsMagnesium compoundsFirst principle calculationsFirst principlesFull-heusler compoundHeusler compoundMaterials stabilityMechanicalPhonon dispersionsPrinciple analysisPropertyShear strainCancer cellsCell cultureCellsControlled drug deliveryDiseasesDrug productsNanostructured materialsPorous materialsTargeted drug deliveryAnti-cancer drug deliveryCovalent organic frameworksImatinibMorphology characterizationsNano scaleSolvothermal reactionsStructure and morphologyStructure characterizationSustained releaseSynthesisedBiocompatibilityAmidesCell deathChemical bondsChemical stabilityChemotherapyEndothelial cellsFourier transform infrared spectroscopyManganeseNuclear magnetic resonance spectroscopyAnderson type manganese polyoxomolybdateAndersonsAnti-cancer agentsEudesmic acidEudesmic acidsMDA-MB-231Organo-conjugatePolyoxomolybdatesQuantum chemical calculationsQuantum-chemical calculationQuantum chemistryEnzymesHydrophobicityMolecular modelingAnti-proliferative activitiesFlow cytometry analysisHydrophobic interactionsImidazopyridinesMolecular dockingMulticomponent synthesisOne-pot synthesisPolycyclic aromatic hydrocarbonsantineoplastic agentcisplatinpalladium complexapoptosisArticlecell cycle assaycell survivalcell viabilitycontrolled studycytotoxicityenzyme linked immunosorbent assayflow cytometryhumanhuman cellIC50K-562 cell lineMTT assayscanning electron microscopyAntineoplastic AgentsCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug DesignDrug Screening Assays, AntitumorHumansIndolesMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipThiosemicarbazones2 [[2 (4 bromophenyl) 1h indol 3 yl]methylidene] n (4 methoxyphenyl)hydrazinecarbothiamide2 [[2 (4 bromophenyl) 1h indol 3 yl]methylidene] n phenylhydrazinecarbothiamide2 [[2 (4 chlorophenyl) 1h indol 3 yl]methylidene] n (4 methoxyphenyl)hydrazinecarbothiamide2 [[2 (4 chlorophenyl) 1h indol 3 yl]methylidene] n phenylhydrazinecarbothiamide2 [[2 (4 hydroxyphenyl) 1h indol 3 yl]methylidene] n phenylhydrazinecarbothiamide2 [[2 (4 hyrdoxyphenyl) 1h indol 3 yl]methylidene] n (4 methoxyphenyl)hydrazinecarbothiamide2 [[2 (4 methoxyphenyl) 1h indol 3 yl]methylidene] n phenylhydrazinecarbothiamide2 [[2 (4 methylphenyl) 1h indol 3 yl]methylidene] n phenylhydrazinecarbothiamidecolchicinecytotoxic agentetoposideindole derivativen (4 methoxyphenyl) 2 [(2 phenyl 1h indol 3 yl)methylidene]hydrazinecarbothioamiden (4 methoxyphenyl) 2 [[2 (3,4,5 trimethoxyphenyl) 1h indol 3 yl]methylidene]hydrazinecarbothioamiden (4 methoxyphenyl) 2 [[2 (4 methoxyphenyl) 1h indol 3 yl]methylidene]hydrazinecarbothioamiden (4 methoxyphenyl) 2 [[2 (4 methylphenyl) 1h indol 3 yl]methylidene]hydrazinecarbothioamiden phenyl 2 [(2 phenyl 1h indol 3 yl)methylidene]hydrazinecarbothioamiden phenyl 2 [[2 (3,4,5 trimethoxyphenyl) 1h indol 3 yl]methylidene]hydrazinecarbothioamidethiosemicarbazone derivativeunclassified drugindoleA-549 cell lineantineoplastic activitydrug cytotoxicitydrug potencydrug screeningdrug synthesisHep-G2 cell linehydrogen bondin vitro studymolecular modelchemical structurechemistrydose responsedrug effectstructure activity relationsynthesistumor cell lineDrug DiscoveryDrug Evaluation, PreclinicalPolymerizationQuantitative Structure-Activity RelationshipTubulinTubulin Modulatorstubulin modulatorbinding affinitybinding sitemicrotubule assemblypharmacophorepredictionreceiver operating characteristicthree dimensional quantitative structure activity relationshipdrug developmentmetabolismpreclinical studyquantitative structure activity relationAntimalarialsArtemisininsBrainDrug CarriersDrug Delivery SystemsLipidsMalariaNanostructuresParasitic Sensitivity TestsParticle SizeTransferrinartemisinindichloromethaneglycerol behenatenanomaterialoleic acidpolysorbate 80transferrin receptorantimalarial agentartemisinin derivativedrug carrierlipidbrain tumordispersitydrug conjugationdrug delivery systemdrug formulationevaporationphysical chemistryprocess optimizationultrasoundX ray diffractionzeta potentialdrug sensitivityA549 CellsApiaceaeGas Chromatography-Mass SpectrometryHEK293 CellsK562 CellsPlant ExtractsPlants, EdiblePlants, Medicinal3 butyldine phthalide3 n butyl phthalide3 octen 1 ol acetatealpha curcumenebeta acoradienebeta farnesenebeta himachalenecaryophyllenecopaenecuparenedelta cadineneessential oilhumuleneKelussia odoratissima extractmethanoln propyl benzenepentyl benzenephthalide derivativeplant extractplant medicinal productsesquiterpene derivativebreast cancer cell linecancer inhibitionembryoHEK293 cell linehydrodistillationKelussia odoratissimamass fragmentographynonhumanovarian cancer cell linephytochemistryplant leafpriority journalroom temperatureedible plantmedicinal plantAdministration, OralCell LineHeLa CellsInsulinTitaniumZirconiumhuman insulinphosphate buffered salinetitanium dioxide nanoparticlewaterzirconium derivativezirconium phosphatetitanium dioxideadsorption kineticscrystal structuredesorptiondrug releasefemalefield emission scanning electron microscopyHeLa cell lineinfrared spectroscopymolecular weightnanoencapsulationpHshelf lifeultraviolet spectroscopyoral drug administrationproceduresAnimalsAntineoplastic Agents, PhytogenicDrug StabilityHalf-LifeMCF-7 CellsMice, Inbred BALB CMicellesNeoplasm TransplantationPaclitaxelTissue DistributionMusalpha tocopherol succinatechitosancremophorfolic acidmacrogolmicelleanimal cellanimal experimentanimal modelanimal tissuebioaccumulationcancer chemotherapycell sizecritical micelle concentrationdrug blood leveldrug distributiondrug eliminationdrug half lifedrug structurein vivo studymouseanimalBagg albino mousecancer transplantationhalf life timeMCF 7 cell lineCell Culture TechniquesCell DifferentiationCell SeparationCells, CulturedCost-Benefit AnalysisIntercellular Signaling Peptides and ProteinsMesenchymal Stromal CellsTime FactorsTissue Culture TechniquesUmbilical CordWharton Jellysignal peptidecomparative studycost benefit analysisculture techniquecytologydrug effectseconomicsmesenchymal stroma cellphysiologytimetissue culture techniqueCyclodextrinsEfficiencyMacromoleculesCarbonyldiimidazoleCritical micelle concentration (cmc)DimethylaminopyridineDissolution methodsDoxorubicinFull factorial designPolydispersity indicesSurface orientationX ray photoelectron spectroscopyAntibiotics, AntineoplasticDextransLeukemia, Myeloid, AcuteTretinoinVitamin B Complexcopolymerdextranfluorescent dyeimidazole derivativepyrenepyridine derivativeretinoic acidantineoplastic antibioticacute granulocytic leukemiacell viability assaychemical analysisconcentration responseconjugationdissolutiondrug uptakeFourier transform infrared photoacoustic spectroscopyIC 50leukemia cellloading efficiencymicellizationpharmacological parametersproton nuclear magnetic resonancerelease efficiencypathology1 (2' hydroxyethyl) 2 methyl 3 benzyloxypyridin 4 one hydrochloride1 (2' hydroxyethyl) 2 methyl 3 hydroxypyridin 4 one hydrochloride1 allyl 2 methyl 3 benzyl oxypyridin 4 one hydrochloride1 allyl 2 methyl 3 hydroxypyridin 4 one1 ethyl 2 methyl 3 benzyloxypyridin 4 one hydrochloride1 ethyl 2 methyl 3 hydroxypyridin 4 one hydrochloride1 ethyl 2 methyl 3 hydroxypyridin hydrochloride1 isobutyl 2 methyl 3 benzyl oxypyridin 4 one hydrochloride1 isobutyl 2 methyl 3 hydroxy pyridin 4 one hydrochloride1 isopropyl 2 methyl 3 benzyl oxypyridin 4 one hydrochloride1 isopropyl 2 methyl 3 hydroxy pyridin 4 one hydrochloride1 propyl 2 methyl 3 hydroxy pyridin 4 one hydrochloride2 methyl 3 benzyloxypran 4 one3 hydroxy 4 pyridone derivativedeferoxamineiron complexmaltolpentetic acidcatalystdrug analysishydrogenationlipophilicitypartition coefficient1,4 dihydropyridine derivativebis isobutyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatedicyclohexyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatedicyclohexylmethyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatedicyclopentyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatedimethoxyethyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateethyl benzyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateethyl isopropyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateethyl methoxyethyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateethyl phenpropyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateisopropyl benzyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateisopropyl cyclohexylmethyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateisopropyl methoxyethyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateisopropyl phenpropyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateisopropyl, tert butyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatemethyl benzyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatemethyl ethyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatemethyl isopropyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatemethyl methoxyethyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatemethyl phenpropyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatecalcium channel blocking activityconformationdensity functional theorydrug activityinfrared spectrometrymalethin layer chromatographyAntitubercular AgentsImidazolesMicrobial Sensitivity TestsMycobacterium tuberculosis1,4 dihydropyridine 3,5 dicarbamoxamide derivative4 [1 benzyl 2 (methylthio) 1h imidazol 5 yl] 2,6 dimethyl n3,n5 bis(3' chlorophenyl) 1,4 dihydropyridine 3,5 dicarboxamide4 [1 benzyl 2 (methylthio) 1h imidazol 5 yl] 2,6 dimethyl n3,n5 bis(4' chlorophenyl) 1,4 dihydropyridine 3,5 dicarboxamide4 [1 benzyl 2 (methylthio) 1h imidazol 5 yl] 2,6 dimethyl n3,n5 bis(pyridin 2 yl) 1,4 dihydropyridine 3,5 dicarboxamide4 [1 benzyl 2 (methylthio) 1h imidazol 5 yl] 2,6 dimethyl n3,n5 bis(pyridin 3 yl) 1,4 dihydropyridine 3,5 dicarboxamide4 [2 (methylthio) 1 (phenylamino) 1h imidazol 5 yl] 2,6 dimethyl n3,n5 bis(2' chlorophenyl) 1,4 dihydropyridine 3,5 dicarboxamide4 [2 (methylthio) 1 (phenylamino) 1h imidazol 5 yl] 2,6 dimethyl n3,n5 bis(pyridin 2 yl) 1,4 dihydropyridine 3,5 dicarboxamideisoniazidrifampicinantibacterial activitycancer cell cultureHeLa cellKga 1 cellleukemia cell lineminimum inhibitory concentrationRaji cellAcute Toxicity TestsBiphenyl CompoundsBornanesCatechol O-MethyltransferaseCatecholsGlucuronosyltransferaseGlutathioneHepatocytesNitrilesPolychlorinated BiphenylsRatsRats, Sprague-DawleyRattusbenzoquinoneborneolcatechol methyltransferase inhibitorchlorineentacaponeglycosyltransferase inhibitorhydroxyl grouppolychlorinated biphenyl derivativesemiquinonecell isolationcorrelation analysisglucuronidationLC 50liver cellliver toxicitymembrane potentialmitochondrial membranemitochondrial toxicityoxidationoxidative stressrattoxicologyAnthraquinonesEvaluation StudiesInhibitory Concentration 502 amino n [4 (2 amino 3 hydroxypropionylamino) 9,10 dioxo 9,10 dihydroanthracen 1 yl] 3 hydroxypropionamide3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromide6 aminohexanoic acid [4 (5 aminopentanoylamino) 9,10 dioxo 9,10 dihydroanthracen 1 yl]amideacetic acid derivativeametantroneanthraquinone derivativechloroformic acid ethyl esterdiamineDNAesterhexanoic acid derivativephenylenediaminephthalic anhydridequinone derivativeserineacetylationcancer cellcancer growthchemical reactioncyclizationFriedel Crafts reactionhydrolysisaltmetric attention scorealtmetricsbibliometricscardiovascular diseaseconceptual modelIranian peoplepublicationscientific literaturescientometricssocial mediaCOVID-19Electronic health recordData cleansingE healthEhealthHealth interventionsPrimary careRemote monitoringText mining techniquesText-miningTopic ModelingTopic modeling text miningTelemedicineAlgorithmsComputational BiologyIranNatural Language Processingalgorithmbioinformaticscancer modelCoronavirinaedata analysisdisease simulationexploratory researchgenetic markerimmunoinformaticsScopussystems biologyunsupervised machine learninganalytic methoddata analysis softwarehealth carehealth educationhealth literacyhierarchical clusteringinformation processingknowledgemedical informationMedical Subject HeadingsMedlinerisktrend studyInternet protocolsNetwork architectureNetwork securitySearch enginesWireless sensor networksClustering approachCo-occurrence wordsHier-archical clusteringHierarchical agglomerative clusteringInternet of thingThematic analysisWeb of ScienceInternet of thingsAdultDisabled PersonsRisk FactorsViolencedisabled personpsychologyrisk factorcorrelation coefficientcorrelational studydecision makingfamily healthfamily studyhuman tissuemajor clinical studymarriagemarried personmental healthmindfulnessmultiple linear regression analysissamplingNumerical methodsSurface watersWind stressBaroclinicMesoscale eddyNumerical modelingPersian GulfThermohaline fluxesThree dimensionalCondensationDrop formationRadiation countersSulfuric acidTungstenTungsten compoundsmetal oxidenanoparticleAdiabatic expansionAerosol particlesCalibration factorsChemical natureCondensation particle countersCut-offDetection efficiencyFuture applicationsGermanyIn-situ dataLaboratory experimentsMeasurement chamberNanometer-sized particlesNew designNucleated particlesPollution measurementTemporal developmentTraffic-relatedTungsten oxideUrban airWorking fluidair pollutionair samplingambient airatmosphereexpansion condensation particle counterhumidityinstrumentlaserlight scatteringmeasurementreliabilityreproducibilitysensorthermodynamicstrafficurban areaUltrasonic effectsConcentration (process)DecompositionFast Fourier transformsOzoneSpectrum analysisTime series analysisSeasonal componentTrend analysisUpper atmosphereAtmospheric pressureCorrelation methodsEigenvalues and eigenfunctionsSingular value decompositionEmpirical orthogonal function (EOF)Sea level pressure (SLP)Sea surface temperature (SST)Weather forecastingMemoryObsessive-Compulsive Disorderdeteriorationeffect sizemeta analysisoutcome variablepublication biasresponsibilityreviewsystematic reviewcomplicationobsessive compulsive disorderAdaptive opticsBinary imagesData acquisitionLaser recordingPhotometryScanningAdaptive sampling intervalCalibration processMulti-shotscannersNovel techniquesPhotometric stereoPoint cloud simplificationsSurface complexitySurface curvaturescalibrationinnovationoptical methodphotometerstereo imagethree-dimensional modelingStereo image processingCancer cellsCell cultureCellsControlled drug deliveryDiseasesDrug productsNanostructured materialsPorous materialsTargeted drug deliveryAnti-cancer drug deliveryCovalent organic frameworksImatinibMorphology characterizationsNano scaleSolvothermal reactionsStructure and morphologyStructure characterizationSustained releaseSynthesisedBiocompatibilityAmidesCell deathChemical bondsChemical stabilityChemotherapyEndothelial cellsFourier transform infrared spectroscopyManganeseNuclear magnetic resonance spectroscopyAnderson type manganese polyoxomolybdateAndersonsAnti-cancer agentsEudesmic acidEudesmic acidsMDA-MB-231Organo-conjugatePolyoxomolybdatesQuantum chemical calculationsQuantum-chemical calculationQuantum chemistryEnzymesHydrophobicityMolecular modelingAnti-proliferative activitiesFlow cytometry analysisHydrophobic interactionsImidazopyridinesMolecular dockingMulticomponent synthesisOne-pot synthesisPolycyclic aromatic hydrocarbonsantineoplastic agentcisplatinpalladium complexapoptosisArticlecell cycle assaycell survivalcell viabilitycontrolled studycytotoxicityenzyme linked immunosorbent assayflow cytometryhumanhuman cellIC50K-562 cell lineMTT assayscanning electron microscopyAntineoplastic AgentsCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug DesignDrug Screening Assays, AntitumorHumansIndolesMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipThiosemicarbazones2 [[2 (4 bromophenyl) 1h indol 3 yl]methylidene] n (4 methoxyphenyl)hydrazinecarbothiamide2 [[2 (4 bromophenyl) 1h indol 3 yl]methylidene] n phenylhydrazinecarbothiamide2 [[2 (4 chlorophenyl) 1h indol 3 yl]methylidene] n (4 methoxyphenyl)hydrazinecarbothiamide2 [[2 (4 chlorophenyl) 1h indol 3 yl]methylidene] n phenylhydrazinecarbothiamide2 [[2 (4 hydroxyphenyl) 1h indol 3 yl]methylidene] n phenylhydrazinecarbothiamide2 [[2 (4 hyrdoxyphenyl) 1h indol 3 yl]methylidene] n (4 methoxyphenyl)hydrazinecarbothiamide2 [[2 (4 methoxyphenyl) 1h indol 3 yl]methylidene] n phenylhydrazinecarbothiamide2 [[2 (4 methylphenyl) 1h indol 3 yl]methylidene] n phenylhydrazinecarbothiamidecolchicinecytotoxic agentetoposideindole derivativen (4 methoxyphenyl) 2 [(2 phenyl 1h indol 3 yl)methylidene]hydrazinecarbothioamiden (4 methoxyphenyl) 2 [[2 (3,4,5 trimethoxyphenyl) 1h indol 3 yl]methylidene]hydrazinecarbothioamiden (4 methoxyphenyl) 2 [[2 (4 methoxyphenyl) 1h indol 3 yl]methylidene]hydrazinecarbothioamiden (4 methoxyphenyl) 2 [[2 (4 methylphenyl) 1h indol 3 yl]methylidene]hydrazinecarbothioamiden phenyl 2 [(2 phenyl 1h indol 3 yl)methylidene]hydrazinecarbothioamiden phenyl 2 [[2 (3,4,5 trimethoxyphenyl) 1h indol 3 yl]methylidene]hydrazinecarbothioamidethiosemicarbazone derivativeunclassified drugindoleA-549 cell lineantineoplastic activitydrug cytotoxicitydrug potencydrug screeningdrug synthesisHep-G2 cell linehydrogen bondin vitro studymolecular modelchemical structurechemistrydose responsedrug effectstructure activity relationsynthesistumor cell lineDrug DiscoveryDrug Evaluation, PreclinicalPolymerizationQuantitative Structure-Activity RelationshipTubulinTubulin Modulatorstubulin modulatorbinding affinitybinding sitemicrotubule assemblypharmacophorepredictionreceiver operating characteristicthree dimensional quantitative structure activity relationshipdrug developmentmetabolismpreclinical studyquantitative structure activity relationAntimalarialsArtemisininsBrainDrug CarriersDrug Delivery SystemsLipidsMalariaNanostructuresParasitic Sensitivity TestsParticle SizeTransferrinartemisinindichloromethaneglycerol behenatenanomaterialoleic acidpolysorbate 80transferrin receptorantimalarial agentartemisinin derivativedrug carrierlipidbrain tumordispersitydrug conjugationdrug delivery systemdrug formulationevaporationphysical chemistryprocess optimizationultrasoundX ray diffractionzeta potentialdrug sensitivityA549 CellsApiaceaeGas Chromatography-Mass SpectrometryHEK293 CellsK562 CellsPlant ExtractsPlants, EdiblePlants, Medicinal3 butyldine phthalide3 n butyl phthalide3 octen 1 ol acetatealpha curcumenebeta acoradienebeta farnesenebeta himachalenecaryophyllenecopaenecuparenedelta cadineneessential oilhumuleneKelussia odoratissima extractmethanoln propyl benzenepentyl benzenephthalide derivativeplant extractplant medicinal productsesquiterpene derivativebreast cancer cell linecancer inhibitionembryoHEK293 cell linehydrodistillationKelussia odoratissimamass fragmentographynonhumanovarian cancer cell linephytochemistryplant leafpriority journalroom temperatureedible plantmedicinal plantAdministration, OralCell LineHeLa CellsInsulinTitaniumZirconiumhuman insulinphosphate buffered salinetitanium dioxide nanoparticlewaterzirconium derivativezirconium phosphatetitanium dioxideadsorption kineticscrystal structuredesorptiondrug releasefemalefield emission scanning electron microscopyHeLa cell lineinfrared spectroscopymolecular weightnanoencapsulationpHshelf lifeultraviolet spectroscopyoral drug administrationproceduresAnimalsAntineoplastic Agents, PhytogenicDrug StabilityHalf-LifeMCF-7 CellsMice, Inbred BALB CMicellesNeoplasm TransplantationPaclitaxelTissue DistributionMusalpha tocopherol succinatechitosancremophorfolic acidmacrogolmicelleanimal cellanimal experimentanimal modelanimal tissuebioaccumulationcancer chemotherapycell sizecritical micelle concentrationdrug blood leveldrug distributiondrug eliminationdrug half lifedrug structurein vivo studymouseanimalBagg albino mousecancer transplantationhalf life timeMCF 7 cell lineCell Culture TechniquesCell DifferentiationCell SeparationCells, CulturedCost-Benefit AnalysisIntercellular Signaling Peptides and ProteinsMesenchymal Stromal CellsTime FactorsTissue Culture TechniquesUmbilical CordWharton Jellysignal peptidecomparative studycost benefit analysisculture techniquecytologydrug effectseconomicsmesenchymal stroma cellphysiologytimetissue culture techniqueCyclodextrinsEfficiencyMacromoleculesCarbonyldiimidazoleCritical micelle concentration (cmc)DimethylaminopyridineDissolution methodsDoxorubicinFull factorial designPolydispersity indicesSurface orientationX ray photoelectron spectroscopyAntibiotics, AntineoplasticDextransLeukemia, Myeloid, AcuteTretinoinVitamin B Complexcopolymerdextranfluorescent dyeimidazole derivativepyrenepyridine derivativeretinoic acidantineoplastic antibioticacute granulocytic leukemiacell viability assaychemical analysisconcentration responseconjugationdissolutiondrug uptakeFourier transform infrared photoacoustic spectroscopyIC 50leukemia cellloading efficiencymicellizationpharmacological parametersproton nuclear magnetic resonancerelease efficiencypathology1 (2' hydroxyethyl) 2 methyl 3 benzyloxypyridin 4 one hydrochloride1 (2' hydroxyethyl) 2 methyl 3 hydroxypyridin 4 one hydrochloride1 allyl 2 methyl 3 benzyl oxypyridin 4 one hydrochloride1 allyl 2 methyl 3 hydroxypyridin 4 one1 ethyl 2 methyl 3 benzyloxypyridin 4 one hydrochloride1 ethyl 2 methyl 3 hydroxypyridin 4 one hydrochloride1 ethyl 2 methyl 3 hydroxypyridin hydrochloride1 isobutyl 2 methyl 3 benzyl oxypyridin 4 one hydrochloride1 isobutyl 2 methyl 3 hydroxy pyridin 4 one hydrochloride1 isopropyl 2 methyl 3 benzyl oxypyridin 4 one hydrochloride1 isopropyl 2 methyl 3 hydroxy pyridin 4 one hydrochloride1 propyl 2 methyl 3 hydroxy pyridin 4 one hydrochloride2 methyl 3 benzyloxypran 4 one3 hydroxy 4 pyridone derivativedeferoxamineiron complexmaltolpentetic acidcatalystdrug analysishydrogenationlipophilicitypartition coefficient1,4 dihydropyridine derivativebis isobutyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatedicyclohexyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatedicyclohexylmethyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatedicyclopentyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatedimethoxyethyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateethyl benzyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateethyl isopropyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateethyl methoxyethyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateethyl phenpropyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateisopropyl benzyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateisopropyl cyclohexylmethyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateisopropyl methoxyethyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateisopropyl phenpropyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylateisopropyl, tert butyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatemethyl benzyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatemethyl ethyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatemethyl isopropyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatemethyl methoxyethyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatemethyl phenpropyl 1,4 dihydro 2,6 dimethyl 4 [2 methylthio 1 (phenylamino) 1h imidazole 5 yl] 3,5 pyridine dicarboxylatecalcium channel blocking activityconformationdensity functional theorydrug activityinfrared spectrometrymalethin layer chromatographyAntitubercular AgentsImidazolesMicrobial Sensitivity TestsMycobacterium tuberculosis1,4 dihydropyridine 3,5 dicarbamoxamide derivative4 [1 benzyl 2 (methylthio) 1h imidazol 5 yl] 2,6 dimethyl n3,n5 bis(3' chlorophenyl) 1,4 dihydropyridine 3,5 dicarboxamide4 [1 benzyl 2 (methylthio) 1h imidazol 5 yl] 2,6 dimethyl n3,n5 bis(4' chlorophenyl) 1,4 dihydropyridine 3,5 dicarboxamide4 [1 benzyl 2 (methylthio) 1h imidazol 5 yl] 2,6 dimethyl n3,n5 bis(pyridin 2 yl) 1,4 dihydropyridine 3,5 dicarboxamide4 [1 benzyl 2 (methylthio) 1h imidazol 5 yl] 2,6 dimethyl n3,n5 bis(pyridin 3 yl) 1,4 dihydropyridine 3,5 dicarboxamide4 [2 (methylthio) 1 (phenylamino) 1h imidazol 5 yl] 2,6 dimethyl n3,n5 bis(2' chlorophenyl) 1,4 dihydropyridine 3,5 dicarboxamide4 [2 (methylthio) 1 (phenylamino) 1h imidazol 5 yl] 2,6 dimethyl n3,n5 bis(pyridin 2 yl) 1,4 dihydropyridine 3,5 dicarboxamideisoniazidrifampicinantibacterial activitycancer cell cultureHeLa cellKga 1 cellleukemia cell lineminimum inhibitory concentrationRaji cellAcute Toxicity TestsBiphenyl CompoundsBornanesCatechol O-MethyltransferaseCatecholsGlucuronosyltransferaseGlutathioneHepatocytesNitrilesPolychlorinated BiphenylsRatsRats, Sprague-DawleyRattusbenzoquinoneborneolcatechol methyltransferase inhibitorchlorineentacaponeglycosyltransferase inhibitorhydroxyl grouppolychlorinated biphenyl derivativesemiquinonecell isolationcorrelation analysisglucuronidationLC 50liver cellliver toxicitymembrane potentialmitochondrial membranemitochondrial toxicityoxidationoxidative stressrattoxicologyAnthraquinonesEvaluation StudiesInhibitory Concentration 502 amino n [4 (2 amino 3 hydroxypropionylamino) 9,10 dioxo 9,10 dihydroanthracen 1 yl] 3 hydroxypropionamide3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromide6 aminohexanoic acid [4 (5 aminopentanoylamino) 9,10 dioxo 9,10 dihydroanthracen 1 yl]amideacetic acid derivativeametantroneanthraquinone derivativechloroformic acid ethyl esterdiamineDNAesterhexanoic acid derivativephenylenediaminephthalic anhydridequinone derivativeserineacetylationcancer cellcancer growthchemical reactioncyclizationFriedel Crafts reactionhydrolysisaltmetric attention scorealtmetricsbibliometricscardiovascular diseaseconceptual modelIranian peoplepublicationscientific literaturescientometricssocial mediaCOVID-19Electronic health recordData cleansingE healthEhealthHealth interventionsPrimary careRemote monitoringText mining techniquesText-miningTopic ModelingTopic modeling text miningTelemedicineAlgorithmsComputational BiologyIranNatural Language Processingalgorithmbioinformaticscancer modelCoronavirinaedata analysisdisease simulationexploratory researchgenetic markerimmunoinformaticsScopussystems biologyunsupervised machine learninganalytic methoddata analysis softwarehealth carehealth educationhealth literacyhierarchical clusteringinformation processingknowledgemedical informationMedical Subject HeadingsMedlinerisktrend studyInternet protocolsNetwork architectureNetwork securitySearch enginesWireless sensor networksClustering approachCo-occurrence wordsHier-archical clusteringHierarchical agglomerative clusteringInternet of thingThematic analysisWeb of ScienceInternet of thingsAdultDisabled PersonsRisk FactorsViolencedisabled personpsychologyrisk factorcorrelation coefficientcorrelational studydecision makingfamily healthfamily studyhuman tissuemajor clinical studymarriagemarried personmental healthmindfulnessmultiple linear regression analysissamplingNumerical methodsSurface watersWind stressBaroclinicMesoscale eddyNumerical modelingPersian GulfThermohaline fluxesThree dimensionalCondensationDrop formationRadiation countersSulfuric acidTungstenTungsten compoundsmetal oxidenanoparticleAdiabatic expansionAerosol particlesCalibration factorsChemical natureCondensation particle countersCut-offDetection efficiencyFuture applicationsGermanyIn-situ dataLaboratory experimentsMeasurement chamberNanometer-sized particlesNew designNucleated particlesPollution measurementTemporal developmentTraffic-relatedTungsten oxideUrban airWorking fluidair pollutionair samplingambient airatmosphereexpansion condensation particle counterhumidityinstrumentlaserlight scatteringmeasurementreliabilityreproducibilitysensorthermodynamicstrafficurban areaUltrasonic effectsConcentration (process)DecompositionFast Fourier transformsOzoneSpectrum analysisTime series analysisSeasonal componentTrend analysisUpper atmosphereAtmospheric pressureCorrelation methodsEigenvalues and eigenfunctionsSingular value decompositionEmpirical orthogonal function (EOF)Sea level pressure (SLP)Sea surface temperature (SST)Weather forecastingMemoryObsessive-Compulsive Disorderdeteriorationeffect sizemeta analysisoutcome variablepublication biasresponsibilityreviewsystematic reviewcomplicationobsessive compulsive disorderAdaptive opticsBinary imagesData acquisitionLaser recordingPhotometryScanningAdaptive sampling intervalCalibration processMulti-shotscannersNovel techniquesPhotometric stereoPoint cloud simplificationsSurface complexitySurface curvaturescalibrationinnovationoptical methodphotometerstereo imagethree-dimensional modelingStereo image processingBioethanolCarbon dioxideCarbon monoxideCombustionEthanolGasolineHydrostatic pressureII-VI semiconductorsNanoparticlesNitrogen oxidesVapor pressureZinc oxideZirconia% reductions1-propanolEngine performanceEngine speedFlash pointsGasoline fuelsNano additivesOptimisationsOxygen-containing additiveVapour pressuresOxygenActivated carbonAnalysis of variance (ANOVA)Effluent treatmentField emission microscopesRefiningActive carbonCarbon catalystsGas refineriesGas refinery effluentPhotocatalytic processProcess efficiencyRefinery effluentsSunlightSynthesis and characterizationsZnO/TiO2-active carbon photocatalystAutomobile fabricsEarningsEconomic analysisHazardsManufacturePolypropylenesTextile industryAutomobile manufacturingEconomic considerationsEconomical analysisLarge scale productionsProcess simulationsProduction capacityPropylene ammoxidationSimulationPlastics industryCathode materialsCathodesCobaltCobalt compoundsLithium compoundsManganese compoundsNickel compoundsSolsAl dopedCharge-discharge characteristicsCycle testsGel methodHigh-efficiencyLithium-ion batteriesComposite beams and girdersConcrete slabsConnectors (structural)Factor analysisSafety factorSensitivity analysisShear flowSustainable developmentAnalysis and evaluationComposite beamDeconstructabilityFlexural resistance factorsHigh-strengthPrecast concrete slabResistance factorsShear connectorSteel beamsSustainable constructionReliability analysisBoltsConcrete beams and girdersConvergence of numerical methodsSteel beams and girdersDeconstructable boltElement modelsFinite element modelingFinite element modelling (FEM)Monte Carlo's simulationProbabilistic analysisSpring modelCodes (standards)DesignFinite element methodBolt shearsDesign strengthEurocodesHigh-strength friction-grip bolt shear connectorPartial factorPush-out testsCarbon steelConcretesConstruction industryCorrosion resistanceEnergy utilizationFrictionJoints (structural components)Plates (structural components)Precast concreteTribologyComposite jointConstruction wastesDeconstructableReducing energy consumptionReinforcement ratiosSteel-concrete composite floorStructural behaviourSustainableHigh strength steelContinuous castingFlowchartingHeuristic algorithmsHeuristic methodsMetal castingMetal castingsNeural networksOptimizationSchedulingSteelSteelmakingAnt colony optimizationCasting productionHybrid algorithm (HA)Hybrid flow shopsMiddle eastNon-linearNon-linear optimizationNumerica l resultsOptimization methodsPerformance efficiencySearch methodsSecond phaseSteel-making-continuous casting schedulingScheduling algorithmsBayes TheoremClimateDNA, PlantDNA, Ribosomal SpacerFabaceaePhylogenySpecies Specificityplant DNAribosomal spacer DNAclassificationspecies differenceAstragalus PlantDNA, IntergenicInflorescenceinternal transcribed spacer 1internal transcribed spacer 2ribosome DNAspacer DNAAstragalus (plant)Astragalus karl-heinziiAstragalus kohrudicusAstragalus remotispicatusAstragalus sciureusDNA sequencemolecular phylogenynomenclatureplant structuresplant taxonomyRNA geneanatomy and histologygeneticsMakranfaunaflyschichnofaciesichnologymarine sedimentMiocenepaleoenvironmenttrace fossilcarbon isotopecarbonate rockdepositional environmentDevoniandiagenesissequence stratigraphyEsfahan [Iran]Chlorine compoundsHealth risksImpuritiesMunicipal solid wastePlastic bottlesRisk assessmentSoil pollutionSoilsWaste managementferrous ionhydrogen peroxidemicroplasticorganic matterpolyacrylonitrilepolyamidepolyesterpolyethylenepolyethylene terephthalatepolyolefinpolypropylenepolystyrenepolyvinylchloridezinc chlorideComposting facilitiesEcological risk indexEcological risksEmerging contaminantEnvironmental concernsIsfahanMicroplasticsMunicipal solid waste compostPolymer compositionSoil pollutantchemical compositioncompostenvironmental riskplasticpolymersoil organic mattercontaminationdensityecosystem healthextractionfood chainhazardmicroplastic pollutionpollution load indexpolymer hazard indexpotential ecological risk indexquality controlRaman spectrometrysamplesludge digestionsoil fertilitysolid waste managementstereomicroscopyCompostingAlternative fuelsBiochemical engineeringCement industryCementsDeveloping countriesRefuse derived fuelsWaste treatmentAlternative energy sourceBiological treatment plantsComprehensive analysisEnvironmental pollutionsEuropean committee for standardizationsMunicipal solid waste (MSW)Physical and chemical analysisReduce energy consumptionalternative energyalternative fuelcement (construction material)developing worldenergy resourceindustrial wastephysicochemical propertyDezful EmbaymentZagrosGeometryOil fieldsRadioactivity loggingTectonicsAghajari fieldAsmari formationsCurvature analysisFracture analysisGeometrical analysisZagros fold-and-thrust beltsanticlinecurvaturefold and thrust beltfracture networkhydrocarbon reservoirlithostratigraphyoil fieldFractureFading channelsFrequency selective fadingInterference suppressionMultiple access interferenceRadio communicationArbitrary pulseCDMA systemCode lengthCode-wordsDifferent frequencyIndoor radio communicationMultiple accessOrthogonal codeOrthogonal spreading codesOrthogonalitySingle usersSpread-timeCode division multiple accessComputational complexityComplexity reductionCoordinated DSLCrosstalk cancellationDigital subscriber lines (DSL)Far-end crosstalk (FEXT)Partial crosstalk cancellationVector codingCrosstalkacrylic acid butyl esteradhesive agentmethacrylic acidpoly(methyl methacrylate)rubberzinc oxide nanoparticleadhesionartificial neural networkcross linkingdifferential scanning calorimetrydispersionemulsionexperimental designFourier transform infrared spectrometershear strengthtensile strengththermogravimetrythermostabilitytransmission electron microscopetransmission electron microscopyAcrylic monomersAcrylicsDynamic light scatteringEncapsulationEstersLatexesNanocomposite filmsNanocompositesPolyacrylatesPolymer blends2-hydroxyethyl methacrylateChemical functionalizationCore shell nano structuresMethylene diphenyl diisocyanateMini-emulsion polymerizationModified SiO2Nano-composite particleThermomechanical propertiesSilica nanoparticlesEngineering geologyRocksSlope protectionSlope stabilityStability criteriaSystem stabilityBlock theoryDiscontinuous rocksEquilibrium approachesFailure mechanismLimit equilibriumLimit equilibrium methodsNatural slopeRock slope stabilitySlope stability analysisStability assessmentlimit analysisrock mechanicsstability analysisFailure (mechanical)Mississippi ValleyUnited StatesAquifersExcavationHealth hazardsCross sectionLateral dimensionLeaking underground storage tanksLow permeabilityMississippi riverNonaqueous phase liquidsSite characterizationUnderground storage tanksWater tablescontaminated landenvironmental assessmentleakagenonaqueous phase liquidpermeabilitysandstorage tanktrap (equipment)underground storagevalleyLandformsBone CementsCementationFemurFinite Element AnalysisMiddle AgedWeight-BearingBiomechanicsBoneBrain computer interfaceCementing (shafts)Compressive strengthComputerized tomographyCracksFailure analysisForecastingFuel tanksRegression analysisSurgerySurgical equipmentTumorsbone cementCompressive testsDistal femoral strengthNonhomogeneityNonlinear behaviorQuantitative computed tomographiesbone injurybone strengthcadavercancer surgeryclinical assessmentclinical evaluationcompressioncomputer assisted tomographycurettagedistal femurfemur fracturefemur tumorfracture fixationquantitative analysisshear stresstreatment failureinjuryweight bearingBituminous paving materialsPreventive maintenanceReinforced plasticsEconomic efficiencyEmulsifierEmulsifier typeGlass-fibersMicrosurfacingMicrosurfacing mixturePavement preservationPerformancePolypropylene fiberStabiliserGlass fibersAir PollutantsDeep Eutectic SolventsGreen Chemistry TechnologyModels, ChemicalSolubilitySolventsSulfur DioxideAir cleanersacetylcholinecoaldeep eutectic solventlevulinic acidorganic solventrainsolventAbsorption modelAcid gasAir-cleaningChemical absorptionGreener solventsSO 2Sustainable solventUNIQUACabsorptionactivity coefficientatmospheric pollutionperformance assessmentchemical industrydata basepractice guidelineskin diseasetemperatureair pollutantchemical modelgreen chemistryCoal combustionBiomassCrystallinityHydrophilicityImpregnationIonic liquidsPore sizeSaccharificationSurface active agentsUltrasonicsCellulose crystallinityEnzymatic digestibilityIonic liquid pretreatmentMorphological featuresSemi-quantitative analysisSimultaneous saccharification and fermentationSurface hydrophilicityUltrasound irradiationCelluloseLigninsLignocelluloseWoodPopulusPopulus tremulaCharacterizationLigninLiquidsTransportationAccessibilityCrystallinitiesPre-TreatmentSimons' stainEuropeProgram EvaluationPublicationsResearch Personnelconceptual frameworkdatabasenetwork analysispublishingsocial networkAsiabalanced scorecardNorth AmericaPacific islandssocial network analysisSouth Americatotal quality managementpersonnel