One-pot synthesis of 2-alkyl-7-amino-5-aryl-pyrazolo[1,5-a]pyrimidine-6- carbonitriles via a domino three-component condensation-oxidation reaction

Abstract

A one-pot, domino three-component condensation reaction of an aldehyde, 3(5)-amino-5(3)-methylpyrazole and malononitrile in ethanol to give 2-alkyl-7-amino-5-aryl-pyrazolo[1,5-a]pyrimidine-6-carbonitrile in high yields at reflux condition without using any catalyst, is described. © 2012 Published by Elsevier Masson SAS on behalf of Academie des sciences.