Type: Article

One-pot synthesis of 2,3-disubstituted-2,3-dihydroquinazolin-4(1H)-ones using [Hmim][NO3]: An eco-friendly protocol

Journal: Journal of Heterocyclic Chemistry (19435193)Year: 2011/11/01Volume: Issue: 6

Mohammadpoor Baltork I.^a Khosropour A.R.Moghadam M.^aTangestaninejad S.^aMirkhani V.^a

a :University of Isfahan - IRAN(IR) - Isfahan

Abstract

An efficient method for the synthesis of a series of 2,3-disubstituted-2,3- dihydroquinazolin-4(1H)-ones is described via one-pot condensation reaction of isatoic anhydride, aryl aldehydes, and primary amines using a Brønsted acidic ionic liquid, [Hmim][NO3], as a catalyst and medium. The present protocol enjoys convenient reaction and simple work-up, greenness, short reaction times, and reusable catalyst as well as mild reaction conditions. Copyright © 2011 HeteroCorporation.

Author Keywords

2,3 disubstituted 2,3 dihydroquinazolin 4(1h) onesaldehydeionic liquidorganic compoundunclassified drug