Synthesis of N-alkyl-2-aryl-5 H-imidazo[1,2-b]pyrazol-3-amines by a three-component condensation reaction

Abstract

An efficient method has been developed for the synthesis of a novel series of N-alkyl-2-aryl-5H-imidazo[1,2-b]pyrazol-3-amines in good-to-high yields by the three-component condensation of an aromatic aldehyde, an aminopyrazole, and an isocyanide in acetonitrile with 4-toluenesulfonic acid as a catalyst at room temperature. © Georg Thieme Verlag Stuttgart - New York.