Type: Article
Synthesis of N-alkyl-2-aryl-5 H-imidazo[1,2-b]pyrazol-3-amines by a three-component condensation reaction
Journal: Synthesis (1437210X)Year: 2011/01/01Volume: Issue: 18Pages: 2913 - 2920
Rahmati A.a Kouzehrash M.A.
DOI:10.1055/s-0030-1260154Language: English
Abstract
An efficient method has been developed for the synthesis of a novel series of N-alkyl-2-aryl-5H-imidazo[1,2-b]pyrazol-3-amines in good-to-high yields by the three-component condensation of an aromatic aldehyde, an aminopyrazole, and an isocyanide in acetonitrile with 4-toluenesulfonic acid as a catalyst at room temperature. © Georg Thieme Verlag Stuttgart - New York.
Author Keywords
aldehydesaminescondensationheterocyclesmulticomponent reactionspolycyclesAcetonitrileAldehydesAminesCondensationCyanidesSynthesis (chemical)
Other Keywords
AcetonitrileAldehydesAminesCondensationCyanidesSynthesis (chemical)2 (4 bromophenyl) 3 [(1,1,3,3 tetramethylbutyl)amino] 5h imidazo[1,2 b]pyrazole 7 carbonitrile2 (4 chlorophenyl) 3 (cyclohexylamino) 5h imidazo[1,2 b]pyrazole 7 carbonitrile2 (4 chlorophenyl) 3 [(1,1,3,3 tetramethylbutyl)amino] 5h imidazo[1,2 b]pyrazole 7 carbonitrile2 (4 chlorophenyl) n cyclohexyl 6 methyl 5h imidazo[1,2 b]pyrazol 3 amine2 biphenyl 4 yl 3 [(1,1,3,3 tetramethylbutyl)amino] 5h imidazo[1,2 b]pyrazole 7 carbonitrile2,2' (1,3 phenylene)bis 3 (cyclohexylamino) 5h imidazo[1,2 b]pyrazole 7 carbonitrile3 (cyclohexylamino) 2 (2,4 dichlorophenyl) 5h imidazo[1,2 b]pyrazole 7 carbonitrile3 (cyclohexylamino) 2 (4 nitrophenyl) 5h imidazo[1,2 b]pyrazole 7 carbonitrile6 tert butyl 2 (4 chlorophenyl) n cyclohexyl 6 methyl 5h imidazo[1,2 b]pyrazol 3 aminen alkyl 2 aryl 5h imidazo[1,2 b]pyrazol 3 amine derivativen biphenyl 4 yl n cyclohexyl 6 methyl 5h imidazo[1,2 b]pyrazol 3 aminen cyclohexyl 6 methyl 2 (4 methylphenyl) 5h imidazo[1,2 b]pyrazol 3 aminen cyclohexyl 6 methyl 2 phenyl 5h imidazo[1,2 b]pyrazol 3 aminepyrazole derivativeunclassified drug4-toluenesulfonic acidAromatic aldehydeEfficient methodHeterocyclesIsocyanidesMulti-component reactionsNovel seriesPolycyclesRoom temperatureThree-componentarticlecatalystchemical reactiondrug structuredrug synthesispolymerizationCondensation reactions