Synthesis of spiro[benzo[h]quinoline-7,3′- Indolines] via a three-component condensation reaction

Abstract

An efficient one-pot synthesis of a new series of spiro[benzo[h]quinoline- 7,3′-indoline] was accomplished simply by the reaction of an isatin, naphthalen-1-amine and a CH-acid (N,N-dimethylbarbituric acid, barbituric acid, dimedone or 1,3-indandion) in acetic acid. During this process, the effects of solvent and temperature have been investigated on the yield of reactions. © Indian Academy of Sciences.