Type: Article
Synthesis of tetrahydrobenzimidazo[1,2-b]quinazolin-1(2H)-one and tetrahydro-1,2,4-triazolo[5,1-b]quinazolin-8(4H)-one ring systems under solvent-free conditions
Journal: Combinatorial Chemistry and High Throughput Screening (13862073)Year: 2006/12/01Volume: 9Issue: 10Pages: 771 - 776
DOI:10.2174/138620706779026060Language: English
Abstract
Tetraheterocyclic benzimidazo[1,2-a]quinazolin-4(1H)-one and tetrahydro-1,2,4-triazolo[5,1-b]quinazolin-8(4H)-one were synthesized in relatively high yields by the condensation reaction of an aldehyde and a cyclic β-diketone with 2-aminobenzothiazole, 2-aminobenzimidazole or 3-amino-1,2,4-triazole without using any catalyst under solventfree conditions. © 2006 Bentham Science Publishers Ltd.
Author Keywords
2-Aminobenzimidazole2-Aminobenzothiazole3-amino-1,2,4-triazoleBiginelli-like reactionCyclic β-diketoneMulticomponent reactionAldehydesAmitroleBenzimidazolesCombinatorial Chemistry TechniquesMolecular StructureQuinazolinesSolventsTriazoles
Other Keywords
AldehydesAmitroleBenzimidazolesCombinatorial Chemistry TechniquesMolecular StructureQuinazolinesSolventsTriazoles12 (3 nitro phenyl) 3,4,5,12 tetrahydrobenzimidazo[2,1 b]quinazolin 1(2h) one12 (4 methoxy phenyl) 3,4,5,12 tetrahydrobenzimidazo[2,1 b]quinazolin 1(2h) one12 (4 methyl phenyl) 3,4,5,12 tetrahydrobenzimidazo[2,1 b]quinazolin 1(2h) one12 (phenyl) 3,4,5,12 tetrahydrobenzimidazole[2,1 b]quinazolin 1(2h) one3,3 dimethyl 12 (2 methoxy phenyl) 3,4,12 trihydrobenzthiazo[2,1 b]quinazolin 1(2h) one3,3 dimethyl 12 (2 methyl phenyl) 3,4,5,12 tetrahydrobenzimidazo[2,1 b]quinazolin 1(2h) one3,3 dimethyl 12 (3 bromo phenyl) 3,4,5,12 tetrahydrobenzimidazo[2,1 b]quinazolin 1(2h) one3,3 dimethyl 12 (3 chloro phenyl) 3,4,5,12 tetrahydrobenzimidazo[2,1 b]quinazolin 1(2h) one3,3 dimethyl 12 (3 methoxy phenyl) 3,4,12 trihydrobenzthiazo[2,1 b]quinazolin 1(2h) one3,3 dimethyl 12 (3 methoxy phenyl) 3,4,5,12 tetrahydrobenzimidazo[2,1 b]quinazolin 1(2h) one3,3 dimethyl 12 (3 nitro phenyl) 3,4,5,12 tetrahydrobenzimidazo[2,1 b]quinazolin 1(2h) one3,3 dimethyl 12 (4 bromo phenyl) 3,4,5,12 tetrahydrobenzimidazo[2,1 b]quinazolin 1(2h) one3,3 dimethyl 12 (4 chloro phenyl) 3,4,5,12 tetrahydrobenzimidazo[2,1 b]quinazolin 1(2h) one3,3 dimethyl 12 (4 methoxy phenyl) 3,4,5,12 tetrahydrobenzimidazo[2,1 b]quinazolin 1(2h) one3,3 dimethyl 12 (4 methyl phenyl) 3,4,5,12 tetrahydrobenzimidazo[2,1 b]quinazolin 1(2h) one3,3 dimethyl 12 (phenyl) 3,4,12 trihydrobenzthiazo[2,1 b]quinazolin 1(2h) one3,3 dimethyl 12 (phenyl) 3,4,5,12 tetrahydrobenzimidazo[2,1 b]quinazolin 1(2h) one6,6 dimethyl 9 (2 methyl phenyl) 5,6,7,9 tetrahydro 1,2,4 triazolo[5,1 b]quinazolin 8(4h) one6,6 dimethyl 9 (3 methoxy phenyl) 5,6,7,9 tetrahydro 1,2,4 triazolo[5,1 b]quinazolin 8(4h) one6,6 dimethyl 9 (3 nitro phenyl) 5,6,7,9 tetrahydro 1,2,4 triazolo[5,1 b]quinazolin 8(4h) one6,6 dimethyl 9 (4 chloro phenyl) 5,6,7,9 tetrahydro 1,2,4 triazolo[5,1 b]quinazolin 8(4h) one6,6 dimethyl 9 (4 methoxy phenyl) 5,6,7,9 tetrahydro 1,2,4 triazolo[5,1 b]quinazolin 8(4h) one6,6 dimethyl 9 (phenyl) 5,6,7,9 tetrahydro 1,2,4 triazolo[5,1 b]quinazolin 8(4h) one9 (3 nitro phenyl) 5,6,7,9 tetrahydro 1,2,4 triazolo[5,1 b]quinazolin 8(4h) one9 (4 methoxy phenyl) 5,6,7,9 tetrahydro 1,2,4 triazolo[5,1 b]quinazolin 8(4h) one9 (4 methyl phenyl) 5,6,7,9 tetrahydro 1,2,4 triazolo[5,1 b]quinazolin 8(4h) one9 (phenyl) 5,6,7,9 tetrahydro 1,2,4 triazolo[5,1 b]quinazolin 8(4h) onequinazolinone derivativetetrahydro 1,2,4 triazolo[5,1 b]quinazolin 8(4h) onetetrahydrobenzimidazol[1,2 b]quinazolin 1(2h) onearticlecarbon nuclear magnetic resonancechemical structurepolymerizationpriority journalproton nuclear magnetic resonancesynthesis