Type: Article
Three-component synthesis of spiro[indoline-3,4'-pyrano[3,2-b]pyran]-2,8'- diones using a one-pot reaction
Journal: Combinatorial Chemistry and High Throughput Screening (13862073)Year: 2014/02/01Volume: 17Issue: 2Pages: 132 - 140
DOI:10.2174/13862073113166660067Language: English
Abstract
A one-pot, three-component reaction of an isatin and kojic acid with an active methylene compound such as ethyl cyanoacetate, methyl cyanoacetate and malononitrile in methanol using catalytic amount of DABCO to give 2'- amino-6'-(hydroxymethyl)-8'H-spiro[indoline-3,4'-pyrano[3,2-b]pyran]-2, 8'-diones in good to excellent yields under reflux conditions, is described. © 2014 Bentham Science Publishers.
Author Keywords
IsatinKojic acidMalononitrileMulti-component reactionPyranopyranonePyrano[3,2-b]pyranoneAcetatesCatalysisCombinatorial Chemistry TechniquesIndolesIsatinNitrilesPiperazinesPyransPyronesSpiro Compounds
Other Keywords
AcetatesCatalysisCombinatorial Chemistry TechniquesIndolesIsatinNitrilesPiperazinesPyransPyronesSpiro Compounds1,4 diazabicyclo[2.2.2]octaneacetic acid derivativecarbenecyanoacetic acid ethyl esterindole derivativekojic acidmalononitrilemethanolmethyl cyanoacetic acidspiro[indoline 3,4' pyrano[3,2 b]pyran] 2,8' dione derivativeunclassified drugarticlechemical reactiondrug synthesisone pot synthesispriority journal