Type: Article

A simple conversion of azlactones into indenones via H3PW 12O40/Al2O3 catalyzed intramolecular Friedel-Crafts reaction

Journal: Tetrahedron Letters (00404039)Year: 28 December 2011Volume: 52Issue: Pages: 7149 - 7152

Rostami M. Khosropour A.R.Mirkhani V.^aMoghadam M.^aTangestaninejad S.^aMohammadpoor Baltork I.^a

a :University of Isfahan - IRAN(IR) - Isfahan

DOI:10.1016/j.tetlet.2011.10.120Language: English

Abstract

A rapid and simple procedure for the synthesis of the indenone derivatives, N-(1-oxo-1H-inden-2-yl)benzamides, via intramolecular Friedel-Crafts (IFC) reaction of (Z)-4-arylidene-2-phenyl-5(4)-oxazolones (azlactones) catalyzed by H3PW12O40 supported on neutral alumina under microwave irradiation has been developed. The reaction is straightforward and allows easy isolation of the product. The catalyst could be re-used up to four times after simple filtration. © 2011 Elsevier B.V. All rights reserved.